Evaluation of diuretic activity of Paspalidium flavidum in rats

Authors

  • - Alamgeer Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Nasir Hayat Malik Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Sajid Bashir Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Abdul Qayyum Khan Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Naveed Mushtaq Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Rashid Department of Pharmacy, University of the Faisalabad
  • Muhammad Akram Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Sadia Samreen Department of Zoology, University of the Punjab, Lahore

DOI:

https://doi.org/10.3329/bjp.v8i2.14243

Keywords:

Diuretic, Furosemide, Paspalidium flavidum, Phytochemical, Rat

Abstract

This study was conducted to investigate the diuretic potential of aqueous methanolic extract of Paspalidium flavidum in rats. The extract at doses of 10, 30 50 and 100 mg/kg was administered intraperitoneally in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. Total urine volume and urinary excretion of electrolytes were measured. Preliminary phytochemical tests were also performed using standard procedures. The extract exhibiteda significant dose dependent diuretic effect at all the doses when compared to control group. Urinary excretion of sodium was significantly increased by the extract while a significant increase in potassium excretion was only observed at higher doses. Phytochemical analysis illustrated that the extract contained compounds such as alkaloids, saponins, tannins, flavonoids, cardiac glycosides and reducing sugars. It is conceivable therefore that the aqueous methanolic extract of P. flavidum contain certain biologically active compounds that might be responsible for the diuretic activity.

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Author Biography

Muhammad Nasir Hayat Malik, Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha

Research Scholar

References

Devi P, Meera R, Muthumani P, Chilakalapudi R, Thota VK, Duddu VD, Murthy, Jeyasundari K. Diuretic activity of whole plant extract of Achyranthes aspera Linn. Int J Pharm Biol Arch. 2010; 1: 331-34.

Du YL, Chen XN. Combinative application of anti-hypertension drugs. World Clin Drugs. 2005; 26: 592-602.

Herrera DM, Abdala S, Benjumea D, Luis JG. Diuretic activity of some Withania aristata Ait fractions. J Ethnopharmacol. 2008; 117: 496-99.

Hussain K, Nisar MF, Majeed A, Nawaz K, Bhatti KH. Ethnomedicinal survey for important plants of Jalalpur Jattan, District Gujrat, Punjab, Pakistan. Ethnobot Leaflets. 2010; 14: 807-25.

Katzung BG. Diuretic agents. In: Basic clinical pharmacology. Katzung BG, Trevor AJ (eds). Singapore, The McGraw-Hill Companies Inc., 2003, pp 244-57.

Khandelwal KR. Practical pharmacognosy. Pune, India, Nirali Prakashan Publishers, 2006, pp 149-53.

Mythreyi R, Rajkumar N, Sasikala E. Evaluation of diuretic activity of Jussiaeasuffruticosa Linn. Pharmacol Online. 2008; 2: 633-39.

Pantoja CV, Chiang LCH, Norris BC, Concha JB. Diuretic, natriuretic and hypotensive effects produced by Allium sativum (garlic) in anaesthetized dogs. J Ethnopharmacol. 1993; 31: 325-31.

Patel SS, Verma NK, Ravi V, Gauthaman K, Soni N. Antihypertensive effect of an aqueous extract of Passiflora nepalensis Wall. Int J App Res Nat Prod. 2010; 3: 22-27.

Stanic G, Samarzija I. Diuretic activity of Saturejamontana subsp. montana extracts and oil in rats. Phytother Res. 1993; 7: 363-66.

Tomassoni AJ, Simone K. Herbal medicines for children: An illusion of safety? Curr Opin Pediatr. 2001; 13: 162-69.

WHO. Guidelines for levels and kinds of evidence to support claims for therapeutic goods, In: General guidelines for methodologies on research and evaluation of traditional medicine. World Health Organization, Geneva, WHO Press, 2000, p 41.

Yuchi A, Malik MNH, Mushtaq MN, Bashir S, Ghumman SA, Akram M, Khan HU, Numan M, Shabbir A. Evaluation of some central nervous system (CNS) activites of aqueous methanolic extract of Paspalidium flavidum Linn. J Med Plant Res. 2012; 6: 3222-27.

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Published

2013-04-22

How to Cite

Alamgeer, .-., M. N. H. Malik, S. Bashir, A. Q. Khan, M. N. Mushtaq, M. Rashid, M. Akram, and S. Samreen. “Evaluation of Diuretic Activity of Paspalidium Flavidum in Rats”. Bangladesh Journal of Pharmacology, vol. 8, no. 2, Apr. 2013, pp. 177-80, doi:10.3329/bjp.v8i2.14243.

Issue

Vol. 8 No. 2 (2013)

Section

Research Articles

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