Hypoglycemic and hypolipidemic effect of Meyna spinosa leaves in high fat diet-alloxan induced type 2 diabetic rats

Authors

  • Saikat Sen Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh
  • Biplab De Department of Pharmaceutical Science, Assam University, Silchar, Assam
  • N. Devanna Oil Technological Research Institute, JNTU Anantapur, Andhra Pradesh
  • Raja Chakraborty Department of Pharmaceutical Chemistry, CES College of Pharmacy, Kurnool, Andhra Pradesh

DOI:

https://doi.org/10.3329/bjp.v8i2.14299

Keywords:

Antidiabetic, Meyna spinosa, folk medicine, leaf, methanol fraction

Abstract

This study investigated the antidiabetic and hypolipedemic action of Meyna spinosa leaf fractions. Effect of methanol, ethyl acetate and petroleum ether fraction (75 and 150 mg/kg p.o.) from M. spinosa leaf methanol extract was evaluated in high fat diet-alloxan induced type 2 diabetic rats after 21 days treatment. Glibenclimide (5 mg/kg), methanol and ethyl acetate fraction at 150 mg/kg exhibited 57.7, 63.4 and 53.8% reduction in serum glucose level after 21 days. Fractions demonstrated significant decrease in triglycerides, total cholesterol, low density lipid, very low density lipid, ?-amylase level, and increase in body weight, high density lipid level in diabetic rats. Fractions showed significant (p<0.05) hypoglycemic effect in glucose loaded animals but not in normal rats. Petroleum ether fraction did not produced significant effect. Result validated the claim made by folk medicinal uses and confirmed the antidiabetic potential of methanol and ethyl acetate fraction of M. spinosa. 

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Author Biographies

Saikat Sen, Department of Pharmacology, CES College of Pharmacy, Kurnool, Andhra Pradesh

Assistant Professor

Raja Chakraborty, Department of Pharmaceutical Chemistry, CES College of Pharmacy, Kurnool, Andhra Pradesh

Pharmaceutical Chemistry

References

Akpan HD, Ekaidem IS, Usoh IF, Ebong PE, Isong NB. Effect of aqueous extract of Azadirachta indica (Neem) leaves on some indices of pancreatic function in alloxan-induced diabetic Wistar rats. Pharmacologia 2012; 3: 420-25.

Al-Shamaony L, Al-Khazraji SM, Twaiji HA. Hypoglycemic effect of Artemisiab herbaalba II. Effect of a valuable extract on some blood parameters in diabetic animals. J Ethnopharmacol. 1994; 43: 167-71.

Bora PJ, Kumar Y. Floristic diversity of Assam: Study of Pabitora wild life sanctuary. Delhi, Daya Publishing House, 2003.

Buragohain J. Phytochemical and antimicrobial investigation on the fruits of Meyna spinosa. Res J Biotechnol. 2008; 3: 372-74.

Das HB, Majumdar K, Datta BK, Ray D. Ethanobotanical uses of some plants by Tripuri and Reang tribes of Tripura. Nat Prod Radiance. 2009; 8: 172-80.

Dewanjee S, Maiti A, Das AK, Mandal SC, Dey SP. Swietenine: A potential oral hypoglycemic from Swietenia macrophylla seed. Fitoterapia. 2009; 80: 249-51.

Goswami S, Bora L, Das J, Begam M. In vitro evaluation of some medicinal plants against Candida albicans. J Cell Tissue Res. 2006; 6: 837-39.

Jain S, Bhatia G, Barik R, Kumar P, Jain A, Dixit VK. Antidiabetic activity of Paspalum scrobiculatum Linn. in alloxan induced diabetic rats. J Ethnopharmacol. 2010; 127; 325-28.

Kannur DK, Hukkeri VI, Akki KS. Antidiabetic activity of Caesalpinia bonducella seed extracts in rats. Fitoterapia 2006; 77: 546-49.

Khan MD, Yadava PS. Antidiabetic plants used in Thoubal district of Manipur, Northeast India. Indian J Trad Knowl. 2010; 9: 510-14.

Liou SS, Liu IM, Hsu JH, Wu YC, Hsu SF, Chen JT. Release of acetylcholine by DieHuangWan to enhance insulin secretion for lowering plasma glucose in Wistar rats. Auton Neurosci. 2002; 100: 21-26.

Mitra S, Mukherjee SK. Some arbortifacient plants used by the tribal people of West Bangal. Nat Prod Radiance. 2009; 8: 167-71.

Nammi S, Boini MK, Lodagala SD, Behara RBS. The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits. BMC Complement Altern Med. 2003; 3: 1-4.

Orhan DD, Aslan M, Sendogdu N, Ergun F, Yesilada E. Evaluation of the hypoglycemic effect and antioxidant activity of three Viscum album subspecies (European mistletoe) in streptozotocin-diabetic rats. J Ethnopharmacol. 2005; 98: 95-102.

Sen S, Chakraborty R, De B, Devanna N. An ethnobotanical survey of medicinal plants used by ethnic people in West and South district of Tripura, India. J For Res. 2011; 22: 417-26.

Shirwaikar A, Rajendran K, Punitha ISR. Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats. J Ethnopharmacol. 2005; 97: 369-74.

Shu X, Lv J, Tao J, Li G, Li H, Ma N. Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan induced diabetic rats. J Ethnopharmacol. 2009; 124: 539-43.

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Published

2013-04-28

How to Cite

Sen, S., B. De, N. Devanna, and R. Chakraborty. “Hypoglycemic and Hypolipidemic Effect of Meyna Spinosa Leaves in High Fat Diet-Alloxan Induced Type 2 Diabetic Rats”. Bangladesh Journal of Pharmacology, vol. 8, no. 2, Apr. 2013, pp. 181-5, doi:10.3329/bjp.v8i2.14299.

Issue

Vol. 8 No. 2 (2013)

Section

Research Articles

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