Hepatoprotective activity of fruit extract of Garcinia pedunculata

Authors

  • Ravi Mundugaru Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi 574118
  • Madhan Chakkravarthy Department of Research and Development, Biomedical Research Unit and Laboratory Animal Center, Saveetha University Thandalam, Chennai 602105
  • Ravishankar Basavaiah Department of Pharmacology and Toxicology, SDM Center for Research in Ayurveda and Allied Sciences, Udupi 574 118

DOI:

https://doi.org/10.3329/bjp.v9i4.19910

Keywords:

Garcinia pedunculata, Hepatoprotective, Paracetamol, Silymarin

Abstract

The objective of this study was to explore the hepatoprotective activity of fruits of Garcinia pedunculata in paracetamol-induced liver toxicity in rats. Paracetamol-induced hepatotoxicity was evaluated by an increase in serum transaminases and alkaline phosphatase activity. Histopathological observation showed extensive disturbance in the liver cytoarchitecture in comparison to normal control liver sections. Pre-treatment with aqueous extract of fruits of G. pedunculata prevented the paracetamol-induced increase in serum transaminases, alkaline phosphatase and histopathological changes. Based on the above observation it can be concluded that G. pedunculata pretreatment exhibited significant hepatoprotective activity against paracetamol-induced hepatotoxicity.

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Author Biographies

Madhan Chakkravarthy, Department of Research and Development, Biomedical Research Unit and Laboratory Animal Center, Saveetha University Thandalam, Chennai 602105

Assistant Professor

Ravishankar Basavaiah, Department of Pharmacology and Toxicology, SDM Center for Research in Ayurveda and Allied Sciences, Udupi 574 118

Professor & Head

References

Bancroft JD, Gamble M. Theory and practice of histological techniques. 5th ed. Churchill Livingstone, 2002.

Bradly DW, Maynard JE, Emery G, Webster H. Transaminase activities in serum of long-term hemodialysis patients. Clin Chem. 1972; 18: 1442.

Dixon MF, Nimmo J, Prescott LF. Experimental paracetamol-induced hepatic necrosis: A histopathological study. J Pathol. 1971: 103; 225-27.

Grosser T, Smyth E, Fitzgerald GA. Anti-inflammatory antipyretic and analgesic agents: Pharmacotherapy of gout. In: Goodman and Gilmans The Pharmacological basis of therapeutics. 11th ed. New York, The MecGrow Companies, 2006, p 983.

Jayaprakasha GK, Negi PS, Jena BS. Anti-oxidative and anti-mutagenic activities of the extracts from the rinds of Garcinia pedunculata. Innov Food Sci Emerg Technol. 2006: 7: 246-50.

Kagyung R, Gajurel P R, Rethy P. Singh B. Ethnomedicinal plants used for gastrointestinaldiseases by Adi tribes of Dehang-Debang Biosphere Reserve in Arunachal Pradesh. Indian J Tradit Know. 2010; 9: 496-501.

Graham G G, Davies M J, Day R O, Mohamudally A, Scott K F. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Inflammopharmacology 2013; 21: 20132.

Larson AM, Polson J, Fontana R J. Acetaminophen-induced acute liver failure: Results of a United States multicenter, prospective study. Hepatology 2005; 42: 136472.

Mundugaru R, Joy F, Shrinidhi R, Das L, Sudhakara, Ravishankar B. Anti-inflammatory activity of aqueous extract of fruits of Garcinia pedunculata in experimental animals. Am J Pharma Tech Res. 2014: 4; 3.

Patiri B, Borah A. Wild edible plants of Assam. 1st ed. Assam, Director Forest Communication, Forest Department, 2007.

Rumack B, Matthew H. Acetaminophen poisoning and toxi-city. Pediatrics 1975; 55: 87176.

Rajesh M J, Latha M S, Hepatoprotection by Elephantopus scaber Linn. in CCL4-induced liver injury. Indian J Physiol Pharmacol. 2001: 45; 481-86.

Sahu A, Das B, Chatterjee A. Polyisoprenylated benzophenones from Garcinia pedunculata. Phytochemistry 1989; 28: 1233-35.

Schmidt E, Schemidt F W, Mohr J, Otto P, Vido I, Wrongeman K, Herfarth C (eds.). In: Pathogenesis and mechanism of liver cell necrosis. 4th ed. Lancester, Medical and Technical Publications, 1975, p 147.

Wilkinson J H, Boutwell J H, Winsten S. Evaluation of a new system for kinetic measurement of serum alkaline phosphatase. Clin Chem. 1969; 15: 487-95.

Additional Files

Published

2014-10-01

How to Cite

Mundugaru, R., M. Chakkravarthy, and R. Basavaiah. “Hepatoprotective Activity of Fruit Extract of Garcinia Pedunculata”. Bangladesh Journal of Pharmacology, vol. 9, no. 4, Oct. 2014, pp. 483-7, doi:10.3329/bjp.v9i4.19910.

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Section

Research Articles