Studies on the antidiabetic effects of Mangifera indica stem-barks and leaves on nondiabetic, type 1 and type 2 diabetic model rats

Authors

  • Amrita Bhowmik Dept of Biochemistry and Molecular Biology, Jahangirnagar University
  • Liakot Ali Khan Dept of Biochemistry and Molecular Biology, Jahangirnagar University
  • Masfida Akhter Dept of Pharmacology, BIRDEM, Dhaka
  • Begum Rokeya Dept of Pharmacology, BIRDEM

DOI:

https://doi.org/10.3329/bjp.v4i2.2488

Keywords:

Antidiabetic, Mangifera indica, Glucose, Prandial, Rat

Abstract

Mangifera indica Linn, locally known as mango tree has been claimed to possess antidiabetic properties by many investigators. The present study was undertaken to screen the hypoglycemic and antihyperglycemic activity of both ethanol and water extracts of leaves and stem-barks of M. indica in nondiabetic and diabetic model rats in different prandial state. The results showed that all of the extracts had significant antihyperglycemic effect in type 2 diabetic model rats when fed simultaneously with glucose load (p<0.05-0.01; p<0.005-0.001). Moreover, the ethanol extract of stem-barks showed significant antihyperglycemic effect when the extract was fed 30 min prior to the glucose load (p<0.01). Investigations were carried out to evaluate the effect of M. indica on glucose absorption using a rat intestinal preparation in situ. The ethanol extracts of stem-barks reduced glucose absorption gradually during the whole perfusion period in type 2 diabetic rats.

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Author Biographies

Amrita Bhowmik, Dept of Biochemistry and Molecular Biology, Jahangirnagar University

Research Fellow

Liakot Ali Khan, Dept of Biochemistry and Molecular Biology, Jahangirnagar University

Professor

Masfida Akhter, Dept of Pharmacology, BIRDEM, Dhaka

Research fellow

Begum Rokeya, Dept of Pharmacology, BIRDEM

Professor

References

Aderibigbe AO, Emudianughe TS, Lawal BAS. Evaluation of the antidiabetic action of Mangifera indica in mice. Phytotherapy Res. 2001; 15: 456-58.

Ali L, Khan AKA, Mamun MIR, Mosihuzzaman M, Nahar N, Nur-E-Alam M, Rokeya B. Studies on hypoglycemic effects of fruit pulp, seed and whole plants of Momordica charantia on normal and diabetic model rats. Planta Medica. 1993; 59: 408-12.

Bonner-Weir S, Trent DF, Honey RN, Weir GC. Responses of neonatal rat islets on streptozotocin-limited beta cell regeneration and hyperglycemia. Diabetes 1981; 30: 64-69.

Creutzfeld W. The incretin concept today. Diabetologia 1979; 16: 75-85.

Lempcke B. Control of absorption: Delaying absorption as a therapeutic principle. In: Structure and function of the Z small Intestine. Cospary WF (ed). New York, Elsevier, 1987, pp 263-80.

Mahabir D, Gulliford MC. Use of medicinal plants for diabetes in Trinidad and Tobago. Rev Panam Salud Publica. 1997: 3: 174-79.

Mamun MIR, Rokeya B, Choudhury NS, Muniruzzaman M, Nahar N, Ahmed MU, Mosihuzzaman M, Ali L, Khan AKA, Khan SH. Anti-hyperglycemic effect of Pterospermum acerifolium Wild and Pterospermum semisagittatum Ham Diabetes Res. 2001; 35: 163-70.

Muruganandan K, Srinivasan S, Gupta PK, Gupta JL. Effect of mangiferin on hyperglycemia and atherogenicityin streptozotocin diabetic rats. J Ethnopharmacol. 2005; 93: 497-501.

Nahar N, Rokeya B, Ali L, Hassan Z, Nur-e-Alam M, Choudhury NS, Khan AKA, Mosihuzzaman M. Effect of three medicinal plants on blood glucose levels in nondiabetic and diabetic model rats. Diabetes Res. 2000: 35: 41-49.

Ojewole J. Anti-inflammatory, analgesic and hypoglycemic effects of Mangifera indica Linn. (Anacardiaceae) stem-bark aqueous extract. Methods Find Exp Clin Pharmacol, 2005: 27: 547-54.

Perpetuo JM, Salgado JM. Effect of mango (Mangifera indica Linn) ingestion on blood glucose levels of normal and diabetic rats. Plant Foods Human Nutr. 2003; 58: 1-12.

Swintosky J, Pogonowska-Wala E. The in situ rat gut technique: A simple, rapid, inexpensive way to study factors influencing drug absorption rate from the intestine. Pharmacy Int. 1982: 3: 163-64.

Sharma SR, Dwivedi SK, Swarup D. Hypoglycemic potential of Mangifera indica leaves in rats. Pharmaceutical Biol. 1997; 35: 130-33.

Trivedi NA, Majumder B, Bhatt JD, Hemavathi KG. Effect of Shilajit on blood glucose and lipid profile in alloxaninduced diabetic rats. Indian J Pharmacol. 2004; 36: 373-76.

Vinik A, Wing RR. In: Diabetes mellitus: Theory and practice. Rifkin H, Porte D Jr. (eds). 2nd ed. New York, Elsevier, 1990, pp 465-97.

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Published

2009-05-20

How to Cite

Bhowmik, A., L. A. Khan, M. Akhter, and B. Rokeya. “Studies on the Antidiabetic Effects of Mangifera Indica Stem-Barks and Leaves on Nondiabetic, Type 1 and Type 2 Diabetic Model Rats”. Bangladesh Journal of Pharmacology, vol. 4, no. 2, May 2009, pp. 110-4, doi:10.3329/bjp.v4i2.2488.

Issue

Vol. 4 No. 2 (2009)

Section

Research Articles

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