Sterculia diversifolia bears anti-cancer and immunomodulatory activities

Authors

  • Fazle Rabbi Department of Pharmacy, University of Peshawar, Peshawar
  • Amir Zada Department of Pharmacy, University of Peshawar, Peshawar
  • Achyut Adhikari HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi http://orcid.org/0000-0002-1065-5727
  • Almas Jabeen Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi http://orcid.org/0000-0002-6043-9539
  • Amna Nisar Department of Pharmacy, University of Peshawar, Peshawar
  • Irfan Ullah Department of Pharmacy, Abasyn University, Peshawar http://orcid.org/0000-0001-5718-1162

DOI:

https://doi.org/10.3329/bjp.v12i1.29516

Keywords:

Anti-cancer, Immunomodulatory, Sterculia diversifolia

Abstract

The present study was aimed to evaluate the methanolic extract and subsequent solvents soluble fractions of Sterculia diversifolia bark for cytotoxic, anti-cancer and immunomodulatory activities. Phytochemical investigation confirmed the presence of alkaloids, flavonoids, saponins, glycosides, etc. In the cytotoxic activity, n-hexane showed potent activity (LD50: 7.0 µg/mL) followed by dichloromethane fraction (LD50: 16.2 µg/mL). In the anti-cancer activity, dichloromethane fraction showed potent activity (IC50: 5.9 µg/mL) followed by ethyl acetate fraction (IC50: 9.5 µg/mL). While in the immunomodulatory assay, ethyl acetate fraction showed a very significant activity (IC50: 21.0 µg/mL) followed by dicloromethane and n-butanol fractions (IC50: 25.0 and 25.3 µg/mL respectively). Hence, it is clear that S. diversifolia has anti-cancer and immunomodulatory agents.

Video Clip of Methodology:

ROS Assay: 2 min 9 sec   Full Screen   Alternate

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Author Biography

Achyut Adhikari, HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi

Assistant Professor

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Additional Files

Published

2017-03-03

How to Cite

Rabbi, F., A. Zada, A. Adhikari, A. Jabeen, A. Nisar, and I. Ullah. “Sterculia Diversifolia Bears Anti-Cancer and Immunomodulatory Activities”. Bangladesh Journal of Pharmacology, vol. 12, no. 1, Mar. 2017, pp. 51-55, doi:10.3329/bjp.v12i1.29516.

Issue

Vol. 12 No. 1 (2017)

Section

Research Articles

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