Hide
Show all
Email this article 
Post a Comment Aqueous extracts of the leaves of Sesbania sesban reduces development of diabetic nephropathy in streptozotocin-induced diabetic rat
Abstract
The renal protective effect of the aqueous extract of Sesbania sesban leaves (250 and 500 mg/kg/day) in streptozotocin-induced diabetic rats were studied. Diabetic rats showed severe hyperglycemia with marked increase in proteinuria and albuminuria. Thye aqueous extract reduced proteinuria, albuminuria, lipid and glycated hemoglobin (HbA1c) deposition in diabetic rats. Histopathology studies on kidneys of diabetic rats revealed severe increase in mesangial cells and matrix of glomeruli with hyaline thickening of some arteriole wall, resulted from selective albuminuria and proteinuria. These changes are inhibited by the extract and glibenclamide. These results suggested that aqueous extract of S. sesban has reduced development of diabetic nephropathy in streptozotocin-induced diabetic rats.
DOI: 10.3329/bjp.v5i2.7592
Keywords
References
Akhtar MS, Ali MR. Study of antidiabetic effect of a compound medicinal plant prescription in normal and diabetic rabbits. J Pak Med Assoc. 1984; 34: 239-44.
Alberti KGMM, CM. Press, The biochemistry and the complications of diabetes In: Complications of diabetes. Keen H, Jarrett J (eds), vol. 43. Edward Arnold Ltd., London, 1982, pp 231-70.
Burrows NR, Wang J, Geiss LS, Venkat Narayan KM, Engelgau MM. Incidence of end-stage renal disease among persons with diabetes e United States, 1990-2002. MMWR Weekly. 2005; 54: 1097-100.
Burstein M, Scholnichk HR, Morin R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res. 1970; 11: 583-95.
Chatterjea MN, Shinde R. Diabetes mellitus: Textbook of medical biochemistry. 5th ed. Jaypee Brothers Medical Publishers Ltd., New Delhi, 1976.
El-Sayed NH. A rare kaempferol trisaccharide anti-tumor promoter from Sesbania sesban. Pharmazie 1991; 46, 679-80.
Eross J, Kreutzman D, Jimenez M, Keen R, Rogers S, Cowell C, Vines R, Silink M. Colorimetric measurement of glycosylated protein in whole blood cells plasma and dried blood. Ann Clin Biochem. 1984; 21: 519-22.
Folch J, Lees M, Solane SGH. A simple method for isolation and purification of total lipids from animal tissues. J Biol Chem. 1957; 26: 497-09.
Foster JB, Dunn RT. Stable reagents for determination of serum triglycerides by colorimetric Hantzsch condensation method. Clin Chem. 1973; 19: 338-40.
Friedwald WT, Levy RI, Fredrickson DS. Estimation of the concentration of LDL-cholesterol in plasma without the use of the preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.
Gupta S, Kataria M, Gupta PK, Murganandan S, Yashroy RC. Protective role of extracts of neem seeds in diabetes caused by streptozotocin in rats. J Ethnopharmacol. 2004; 90: 185-89.
Hink U, Li H, Mollnau H. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res. 2001; 88: e14-22.
Jain SR, Hypoglycemic principal in the Musa sapeintum and its isolation. Planta Medica. 1968; 1: 43-47.
Kesari AN, Gupta RK, Watal G. Hypoglycemic effects of Murraya koenigii on normal and alloxan diabetic rabbits. J Ethnopharmacol. 2005; 97: 247-51.
Khare CP. Indian medicinal plants: An illustrated dictionary. Springer, Verlag Berlin, 2007, p 601.
Leese GP, Savage MW, Chattington PD, Vora JP. The diabetic patient with hypertension. Postgraduate Med J. 1996; 72, 263-68.
Pari L, Saravanan G. Antidiabetic effect of Cogent db, a herbal drug in alloxan-induced diabetes mellitus. Comp Biochem Physiol. C: Pharmacol Toxicol Endocrinol. 2002; 131: 19-25.
Ramdas B. Pandhare, B. Sangameswaran, Popat B. Mohite, Shantaram G. Khanage. Antidiabetic activity of aqueous leaves extract of Sesbania sesban (L) Merr. in streptozotocin-induced diabetic rats. 2011; 3: 37-43.
Schnachenberg CG. Oxygen radicals in cardiovascularerenal disease. Curr Opin Pharmacol. 2002; 2: 121-25.
Sohn EJ, Kim CS, Kim YS, Jung DH, Jang DS, Lee YM, Kim JS. Effects of magnolol (5,50-diallyl-2, 20-dihydroxybiphenyl) on diabetic nephropathy in type 2 diabetic Goto-Kakizaki rats. Life Sci. 2007; 80: 468-75.
Susztak K, Raff AC, Schiffer M. Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 2006; 55: 225-33.
Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatment for diabetes: studies in normal and streptozotocin diabetic mice. Diabetologia 1990; 33: 462-64.
Upadhyaya JS, Singh SP. Chromatographic studies of oxidation products of lignin from Sesbania sesban. Cellul Chem Technol. 1991; 25: 219-26.
Yusuf M, Chowdhury JU, Wahab MA, Begum J. Medicinal plants of Bangladesh. BCSIR, Dhaka, Bangladesh. 1994, p 223.
Zlatkis A, Zak B, Boyle AJ. A new method for the direct determination of serum cholesterol. J Lab Clin Med. 1953; 41: 486–92.
This work is licensed under a Creative Commons Attribution 3.0 License.
IndexCopernicus 2009 value: 9.00; 2010 value: 9.00
SJR h-index 2009 value: 3.00; 2010 value: 4.00
Downloaded by more than 5,000 readers: Saha MR, Alam MA, Akter R, Jahangir R. In vitro free radical scavenging activity of Ixora coccinea L. Bangladesh J Pharmacol. 2008; 3: 90-96.
On average 907 downloads per research article (pdf); 1329 registered user (22 April 2012).
On average 846 downloads per research article (pdf); 1225 registered user (22 December 2011).
On average 814 downloads per research article (pdf); 1117 registered user (22 August 2011).
Abstracted/indexed in (19): Academic Search Complete, Agroforestry Abstracts, Arts & Humanities Citation Index, Asia Journals Online, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, Directory of Open Access Journals, EMBASE/Excerpta Medica, Forest Products Abstracts, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index.
For longterm preservation, the journal has been archived in the e-Depot archive.
Journal impact analysis 4-years (Harzing's Publish or Perish):
Citation/year: 81.80; Citation/paper: 3.12; h-index: 10.0 (March 20, 2012)
Citation/year: 54.25; Citation/paper: 2.13; h-index: 8.0 (September 8, 2011)
Citation/year: 42.25; Citation/paper: 1.67; h-index: 7.0 (May 29, 2011)
Citation/year: 34.25; Citation/paper: 1.36; h-index: 6.0 (March 13, 2011)
Citation/year: 31.67; Citation/paper: 1.02; h-index: 5.0 (September 2, 2010)
Available in institutional webpage (20): Bangabandhu Sheikh Mujib Medical University; Eastern Michigan University Library;Halmstad University, Sweden; John Hopkins University; National Taiwan University; Oxford University; San Jose State University; Tel Aviv University; Tokyo University of Agriculture; University of Hong Kong; University of Maine; University of Nevada; University of North Carolina; University of Oklahama; University of Saskatchewan; University of Toronto; University of Washington; University of Windsor; Vrije Universiteit Brussel; York University
The Bangladesh Journal of Pharmacology does not accept responsibility for views expressed in articles, mini-reviews, and other contributions that appear in its pages.