https://www.banglajol.info/index.php/BJP/issue/feedBangladesh Journal of Pharmacology2024-03-14T18:45:44+00:00Mir Misbahuddindgdabd@gmail.comOpen Journal Systems<p id="isPasted">The <em>Bangladesh Journal of Pharmacology</em> (Bangladesh J Pharmacol) is an open-access, video-component, and peer-reviewed biomedical science journal of the Bangladesh Pharmacological Society (BDPS).</p> <p>The journal publishes papers on the studies of plant extracts or drugs on pharmacological effects using lab animals, human cell lines, and microbes.</p> <p>The papers are Research Articles, Mini-review, Meta-analyses, Clinical Trials, Visual Experiments, and Letter to the Editor. Those who want to publish a research article must submit a video clip of one of the methodologies. Mini-reviews and Meta-analyses are usually unsolicited. A letter to the Editor is acceptable where the author(s) has data with minor dissimilarities from others' published data.</p> <p>The studies on antihypertensive drugs, anti-HIV agents, molecular docking without the data of wet lab, nanotechnology, and polyherbal products are not in the scope of this journal.</p> <p>The author will not be charged in the form of submission fee, article processing fee or publication fee. It is completely free. We do not publish any advertisement.</p> <p>The journal publishes four online issues (January, April, July, and October) per year.</p> <p><strong>Journal Metrics</strong><br />Journal metrics allow you to compare journals, regardless of their subject classification.<br />Impact Factor<sup>®</sup> as reported in the 2022 Journal Citation Reports<sup>®</sup>: <strong>1.6</strong></p> <h2><img src="https://www.banglajol.info/public/site/images/misbah/if.jpg" alt="" /></h2> <p>CiteScore (2021): <strong>2.0</strong> <a href="https://www.scopus.com/sourceid/18200156711">Current month's CiteScore Tracker</a><br />H index (2022): <strong>28 </strong>(It means 28 articles of this journal have more than 28 number of citations)</p> <p><strong>Abstracted/Indexed in</strong><br />Academic Search Complete, Bangladesh Journals Online, Biological Abstracts, BIOSIS Previews, CAB Abstracts, Current Abstracts, <a href="http://bit.ly/2r4KLsU">Directory of Open Access Journals</a>, EMBASE/Excerpta Medica, Global Health, Google Scholar, HINARI (WHO), International Pharmaceutical Abstracts, Open J-gate, Science Citation Index Expanded, SCOPUS and Social Sciences Citation Index</p> <p><strong>Members</strong><br />Bangladesh Journal of Pharmacology is the member of <a href="https://oaspa.org/member/bangladesh-journal-of-pharmacology/">OASPA</a> (Open Access Scholarly Publishers Association), <a href="http://publicationethics.org/">COPE</a> (Committee on Publication Ethics), The International Society of Managing and Technical Editors (<a href="http://www.ismte.org/members/">ISMTE</a>) and Asian Council of Science Editors.</p>https://www.banglajol.info/index.php/BJP/article/view/70296Anti-diabetic activity of Calathea anulque2023-12-07T07:24:12+00:00Saranya Shankarsaranyashankar130@gmail.comChitrashalini Srinivasanchitrashalini2001@gmail.comMythili Sathiavelusmythili@vit.ac.in<p>No abstract</p>2024-03-14T00:00:00+00:00Copyright (c) 2024 Saranya Shankar, Chitrashalini Srinivasan, Mythili Sathiaveluhttps://www.banglajol.info/index.php/BJP/article/view/70297Synthesis, molecular modeling, anti-cancer and COX-1/2 inhibitory activities of novel thiazolidinones containing benzothiazole core2023-12-07T08:29:38+00:00Necla Kulabasnecla.kulabas@marmara.edu.trCansu Tamniku Guvencansutamnik@gmail.comMerve Duracıkmerveduracik@gmail.comOzlem Bingol Ozakpınarozlemozakpinar@gmail.comİlkay Kucukguzelkucukguzel@hotmail.com<p>In this study, new 1,3-thiazolidin-4-one derivatives containing arylmethylene groups in the 5-position were obtained from 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine (riluzole). Synthesized compounds were characterized by spectral data and elemental analysis. <em>In vitro</em>, cytotoxic activities of the synthesized molecules were evaluated against the human lung cancer (A549) and human prostate cancer (PC-3) cell lines. Compounds were also tested on mouse embryonic fibroblast cells (NIH/3T3) to determine selectivity. Ten target compounds <strong>3</strong>-<strong>12</strong> were also screened for their COX-1 and COX-2 inhibitory activities. Of these compounds, <strong>4</strong> showed the highest COX-2 inhibition at 10 μM. Molecular docking calculations were performed to understand the binding interactions of compounds with COX-1 and COX-2 proteins. <em>In silico</em> studies of the tested compounds represented important binding modes that may be responsible for their anti-cancer activity via selective inhibition of the COX-2 enzyme. ADMET predictions were conducted to assess the drug-like properties of the novel compounds.</p>2024-03-14T00:00:00+00:00Copyright (c) 2024 Necla Kulabas, Cansu Tamniku Guven, Merve Duracık, Ozlem Bingol Ozakpınar, İlkay Kucukguzelhttps://www.banglajol.info/index.php/BJP/article/view/70889Berberine triggers necroptosis of cervical H8 cells by activating receptor-interacting protein kinase 12024-01-19T05:43:42+00:00Mengting Wangwmt1005xz@126.comHuixian Chenchenhuixiandy@163.comQian Wu654504546@qq.comYan Huang1771479075@qq.comYuzhen Zhouzhouyuzhen100@sina.com<p>This study aims to investigate the effect of berberine on necroptosis in cervical H8 cells. CCK-8 assay was used to assess cell proliferation activity. The expression levels of necroptosis key markers Receptor-interacting protein kinase 1 (RIPK1), MLKL, p-MLKL, and apoptosis-related caspase-8, caspase-3 were analyzed through qRT-PCR, western blot, and immunofluorescence. Mechanistic studies were conducted using the RIPK1 kinase inhibitor necrostatin-1 (Nec-1). The results showed that berberine could inhibit H8 cell proliferation in a time- and dose-dependent manner (p<0.05). It increased the expression of RIPK1 and MLKL (p<0.05), while inhibiting the expression of caspase-8 and caspase-3 (p<0.05). Nec-1 inhibitor decreased the expression of RIPK1 and MLKL after the intervention of berberine (p<0.05). Therefore, berberine induces cervical H8 cell death through the activation of RIPK1-mediated necroptosis.</p>2024-03-14T00:00:00+00:00Copyright (c) 2024 Mengting Wang, Huixian Chen, Qian Wu, Yan Huang, Yuzhen Zhouhttps://www.banglajol.info/index.php/BJP/article/view/71024In vitro anti-cancer activity of Epipremnum aureum2024-01-17T14:41:07+00:00Sudhir S. Patilsudhirs.pharmac@gmail.comKiran A. Wadkarkiranwadkar@rediffmail.com<p>In the present study, <em>in vitro </em>anti-cancer activity of aerial parts of <em>Epipremnum aureum </em>extracts was performed using the MCF-7 breast cancer cell line. Soxhlet method was used with different solvents for extract preparation. The amount of apoptosis in MCF-7 cells was assessed using flow cytometry for each of the extracts. The chloroform and ethanol extracts had a considerable cytotoxic effect with IC<sub>50</sub> values of 32.9 and 45.8 μg/mL respectively, while the conventional medication 5-fluorouracil produced an IC<sub>50</sub> value of 19.2 μg/mL. The microscopic examination of the chloroform and ethanol extracts of <em>E. aureum</em> revealed the presence of apoptotic bodies, nuclear fragmentation, and tiny nuclei with strong chromatin condensation. These results suggest that chloroform extract of <em>E. aureum</em> is more effective against breast cancer. </p>2024-03-14T00:00:00+00:00Copyright (c) 2024 Sudhir S. Patil, Kiran A. Wadkarhttps://www.banglajol.info/index.php/BJP/article/view/71069Nigella sativa plant extract inhibits the proliferation of MDA-MB-231 breast cancer cells via apoptosis and cell cycle arrest 2024-01-19T18:37:30+00:00Jie Majiema.onco@hotmail.comCong Pengq032686@163.com<p>The study was designed to evaluate the antiproliferative effects of <em>Nigella sativa</em> plant ethanol extract against MDA-MB-231 triple-negative breast cancer cells. DAPI and annexin V/propidium iodide staining assays were used to examine apoptosis. Results showed that <em>N. sativa</em> extract significantly (p<0.05) impeded the growth of MDA-MB-231 cells, with IC<sub>50</sub> of 12.5 μg/mL. The colony-forming potential of MDA-MB-231 was significantly (p<0.05) decreased by the <em>N. sativa</em> extract-induced apoptosis. Increased expression of Bax, caspase-3, cleaved caspase-3, and cleaved PARP was also observed in the extract-treated MDA-MB-231 cells. Moreover, flow cytometric analysis showed that <em>N. sativa </em>extract triggered G<sub>0</sub>/G<sub>1</sub> phase arrest in MDA-MB-231 cells. Collectively, <em>N. sativa</em> extract exhibits potent antiproliferative activity against triple-negative breast cancer cells and may be used as a source of anti-cancer agents.</p>2024-03-14T00:00:00+00:00Copyright (c) 2024 Jie Ma, Cong Peng