Bioactive traditional plant Cinnamomum zeylanicum successfully combat against nephrotoxic effects of aminoglycosides
DOI:
https://doi.org/10.3329/bjp.v8i1.12862Keywords:
Aminoglycosides, Cinnamomum zeylanicum, Dal chini, Rabbit, Renal damageAbstract
Cinnamomum zeylanicum is traditionally used for the treatment of bladder and kidney problems; believed to have kidney tonic effects. The prime objective of the current study was to explore the nephroprotective effects of the plant due to its strong antioxidant properties, to provide experimental facts for their traditional use. Daily dose of 200 mg/kg of plant extract was employed alone and in combination with gentamicin for a period of twenty one days in rabbits. Biochemical kidney functioning parameters were assessed thrice throughout study period. Histopathological examination of the kidneys was performed on the last day of experimental period. Present study showed that C. zeylanicum significantly attenuated renal functional and histological changes associated with gentamicin as assessed by urea, creatinine, uric acid, electrolytes, urinary protein, and histopathological examination. The plant extract successfully proved to have strong nephroprotective properties, especially against aminoglycosides induced nephrotoxicities.
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