Dyslipidaemia in Schizophrenia

Authors

  • Syeda Marufa Hasan Assistant Professor, Department of Biochemistry, National Institute of Laboratory Medicine and Referral Center, Dhaka
  • Nasima Sultana Directorate General of Health Services, Mohakhali, Dhaka
  • SM Abdul Awual Department of ENT, Sir Salimullah Medical College, Dhaka
  • Shamim Are Ferdous Department of Biochemistry, Shaheed M. Monsur Ali Medical College, Sirajganj
  • Molla Amiruzzaman Department of Biochemistry, National Institute of Laboratory Medicine and Referral Center, Dhaka

DOI:

https://doi.org/10.3329/akmmcj.v13i1.64715

Keywords:

Dyslipidaemia, Schizophrenia, Risk factors

Abstract

Background: Lipid neurochemistry is an important focus in schizophrenia research. Disorder of fatty acid metabolism within the brain tissue play an important role in the pathophysiology of schizophrenia.

Material & Methods: To evaluate the association of dyslipidaemia with Schizophrenia and compare the serum lipid profile with healthy individuals, a cross sectional analytical study was conducted between July 2011 and June 2012 in the Department of Biochemistry, Dhaka Medical College, following approval of a protocol. As per criteria, total 100 cases were included in this study and divided into two groups: Group-I (Diagnosed cases of schizophrenia) and Group-II (Healthy individuals). Written informed consent was taken from all cases. Serum lipid profile (Total Cholesterol, Triglycerides, HDL and LDL) was estimated from both groups by enzymatic determination.

Result: Fasting serum triglyceride (p<0.03), HDL cholesterol (p<0.001) and LDL cholesterol (p<0.001) between the groups are significantly related. In group-I mean serum HDL cholesterol is reduced, but LDL cholesterol and Triglyceride were elevated in comparison with group-II. No significant relationship was observed in fasting serum total cholesterol in between groups (p>0.05). Result indicates strong association between schizophrenia and dyslipidaemia. That association would increase the risk of developing coronary heart disease in those patients with schizophrenia compared with healthy individual.

AKMMC J 2022; 13(1) : 8-13

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Published

2021-12-28

How to Cite

Hasan, S. M. ., Sultana, N. ., Awual, S. A. ., Ferdous, S. A., & Amiruzzaman, M. . (2021). Dyslipidaemia in Schizophrenia. Anwer Khan Modern Medical College Journal, 13(1), 8–13. https://doi.org/10.3329/akmmcj.v13i1.64715

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Section

Original Articles