HELLP syndrome: An experience of treating with plasma exchange
Keywords:HELLP, Preeclampsia, Therapeutic Plasma Exchange
In the spectrum of patient with severe pre-eclampsia, there is a potentially lethal complication called HELLP syndrome( haemolysis, elevated liver enzyme and low platelet count).1 The pathogenesis of HELLP syndrome is unclear. If it is a form of severe preeclampsia, it likely originates from aberrant placental development and function. As an independent entity, it has been attributed to abnormal placentation, similar to preeclampsia, but with greater hepatic inflammation and greater activation of the coagulation system than in preeclampsia.2,3,4 HELLP develops in approximately 0.5 to 0.9 percent of all pregnancies and in 10 to 20 percent of women with severe preeclampsia/eclampsia.5 Maternal mortality rate in HELLP syndrome is variable(1-23%) due to severity of disease, delayed diagnosis and presence of multi-organ involvement.6,7 So the recognition of HELLP syndrome and an aggressive multidisciplinary approach are required for the improvement of meternofoetal prognosis.
Bangladesh Crit Care J September 2013; 1 (2): 102-103
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