Raised Arterial Pressure and Microalbuminuria in Type 2 Diabetic Subjects with Familial Hypertension

Authors

  • Md Anisur Rahman Junior Consultant, Nephrology and Dialysis, BIRDEM General Hospital, Dhaka
  • Md Mostarshid Billah Junior Consultant, Nephrology and Dialysis, BIRDEM General Hospital, Dhaka
  • Palash Mitra Assistant Registrar, Nephrology and Dialysis, BIRDEM General Hospital, Dhaka
  • Md Emtiaz Hossan Senior Medical Officer, Nephrology and Dialysis, BIRDEM General Hospital, Dhaka
  • Md Jakir Hossain Senior Medical Officer, Nephrology and Dialysis, BIRDEM General Hospital, Dhaka
  • Wasim Md Mohosin Ul Haque Associate Professor, Nephrology, BIRDEM General Hospital, Dhaka
  • Md Abul Mansur Professor, Nephrology and Dialysis; Director, Transplant Unit, BIRDEM General Hospital, Dhaka

DOI:

https://doi.org/10.3329/bccj.v4i1.27973

Keywords:

Hypertension, microalbuminuria, diabetes mellitus, familial predisposition to hypertension and diabetic nephropathy

Abstract

Background and Aims : Microalbuminuria is claimed to be an early marker of nephropathy in type 2 diabetes.The raised arterial pressure is an important factor in the progression of diabetic nephropathy. There is a significant correlation between blood pressure and the progression of albuminuria in both type 1 and type 2 diabetes. This study in Bangladeshi type 2 diabetic patients was to evaluate whether microalbuminuria and raised arterial pressure are influenced by familial predisposition to hypertension.

Methods : Sixty three newly diagnosed Bangladeshi type 2 diabetic patients were investigated. The diabetic subjects were divided into two groups as diabetes with family history of hypertension (n=37) and diabetes without family history of hypertension (n=26). Diabetic subjects were further divided into normotensive (n= 46) and hypertensive (n= 17); diabetic normoalbuminuric (n 44) and diabetic microalbuminuric (n 19) subgroups. Serum glucose was measured by glucose-oxidase; blood urea, serum creatinine and urinary creatinine by enzymatic-colorimetric method and urinary albumin by immunoturbidimetry method.

Results : systolic blood pressure (SBP), diastolic blood pressure (DBP) and microalbuminuria were significantly elevated in diabetic subjects with familial predisposition to hypertension when compared to diabetic subjects without familial predisposition to hypertension [SBP (127±16 vs 110±14) mmHg P= 0.001; DBP (81±9 vs 72±11) mmHg P= 0.001; Microalbuminuria 2.23(0.28-9.43) vs 1.52(.29-3.91) mg/mmol p<0.03]. When diabetic normotensive subjects were compared with diabetic hypertensive subjects for microalbuminuria, no significant difference was found among themselves [median (range) 1.67(0.17-8.62) vs 1.70(.28-9.43) mg/mmol p = NS]. Comparison of blood pressure was found no significant difference between diabetic normoalbuminuric and diabetic microalbuminuric subjects [systolic blood pressure (117±17 vs 125±17) mmHg p= NS ; diastolic blood pressure (76±11 vs 82±10) mmHg p= NS ].

Conclusion : Microalbuminuria, a marker of early diabetic nephropathy and raised arterial pressure, a progression factor of nephropathy are more influenced by familial predisposition to hypertension in diabetic population irrespective of presence or absence of microalbuminuria and hypertension.

Bangladesh Crit Care J March 2016; 4 (1): 14-18

Downloads

Download data is not yet available.
Abstract
121
PDF
94

Author Biography

Md Anisur Rahman, Junior Consultant, Nephrology and Dialysis, BIRDEM General Hospital, Dhaka



Downloads

Published

2016-06-01

How to Cite

Rahman, M. A., Billah, M. M., Mitra, P., Hossan, M. E., Hossain, M. J., Haque, W. M. M. U., & Mansur, M. A. (2016). Raised Arterial Pressure and Microalbuminuria in Type 2 Diabetic Subjects with Familial Hypertension. Bangladesh Critical Care Journal, 4(1), 14–18. https://doi.org/10.3329/bccj.v4i1.27973

Issue

Vol. 4 No. 1 (2016)

Section

Original Articles

License

Upon acceptance for publication the copyright of the paper automatically transfers to the BCCJ and will not be published elsewhere either in part or whole without written permission of the copyright holder.

Except for personal use, no part of the materials published in this journal may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, photocopying, recording or otherwise without the prior written permission of the publisher.