A Case Study on Pemphigus Vulgaris

Authors

  • Rabita Nur Mannan Physician, Bangladesh Medical and Dental College, Dhanmondi, Dhaka, Bangladesh
  • Afsana Chowdhury Physician, Bangladesh Medical and Dental College, Dhanmondi, Dhaka, Bangladesh
  • Afia Mahmuda Khan Physician, Bangladesh Medical and Dental College, Dhanmondi, Dhaka, Bangladesh
  • Fannana Nowshin Physician, Bangladesh Medical and Dental College, Dhanmondi, Dhaka, Bangladesh.
  • Md Tarek Alam Professor, Department of Medicine, Bangladesh Medical College, Dhanmondi, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bccj.v11i2.69161

Keywords:

Pemphigus, Autoimmune, Dental Awareness

Abstract

Pemphigus vulgaris is a chronic autoimmune mucocutaneous disease that is primitively demonstrated in the form of intraoral lesions extending to other mucous membranes and the skin. The origin of pemphigus vulgaris is unknown, even though the disease has prompted considerable interest. It is marked by the existence of circulating IgG antibodies directed against desmosomes, which are skin components that retain particular layers of skin bound to one another. When desmosomes are attacked, the skin layer separates, and the clinical presentation resembles a blister. Oral lesions are vesiculobullous at first but easily rupture, with new bullae attempting to form as the older one’s rupture and ulcerate. A biopsy of perilesional tissue and histological and immunostaining examination is required for a correct diagnosis. The current standard of treatment relies mainly on systemic immunosuppression with corticosteroids, azathioprine, or other adjuvants, but newer therapies with possibly fewer adverse effects also seem promising.

Bangladesh Crit Care J September 2023; 11 (2): 137-139

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Published

2023-10-04

How to Cite

Rabita Nur Mannan, Afsana Chowdhury, Afia Mahmuda Khan, Fannana Nowshin, & Alam, M. T. . (2023). A Case Study on Pemphigus Vulgaris. Bangladesh Critical Care Journal, 11(2), 137–139. https://doi.org/10.3329/bccj.v11i2.69161

Issue

Vol. 11 No. 2 (2023)

Section

Case Reports

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