Association of free Tri-iodothyronine Level with Cardiogenic Shock and Prognosis in Patients Hospitalized with Acute STelevation Myocardial Infarction Treated with Streptokinase Therapy

Authors

  • S M Nazmul Huda Assistant Registrar, Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh
  • Amal Kumar Choudhury Professor of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh
  • Jafrin Jahan Associate Professor of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh
  • Masuma Tabassum Resident, Department of Pharmacology, Bangabandhu Sheikh University, Dhaka, Bangladesh
  • Atikur Rahman Assistant Registrar, Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh
  • Deb Dulal Debnath Medical officer, Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bhj.v38i1.67187

Keywords:

FT3, Cardiogenic shock, STEMI, MACE.

Abstract

Background: Cardiogenic shock is the leading cause of death in patients with Acute ST-segment Elevation Myocardial Infarction (STEMI). Low free Tri-iodothyronine (FT3) levels are generally associated with poor prognosis in STEMI patients. This study was done to assess the association between FT3 levels and Cardiogenic shock in patients hospitalized with STEMI treated with streptokinase therapy.

Methods: This was an observational study of 140 patients of STEMI treated with streptokinase therapy in the department of cardiology, NICVD, Dhaka, Bangladesh from October 2018 to September 2019. The patients were divided into low FT3 (FT3 <3.5pmol/L; n = 70) and normal FT3 (FT3 e” 3.5pmol/L; n = 70) groups according to FT3 levels measured within 24 hours after admission.

Results: During the index hospitalization period, 30 patients developed cardiogenic shock, 23(32.9%) in low FT3 group and 7(10.0%) in normal FT3 group. There were 17 deaths with 18.6% in low FT3 group and 5.7% in normal FT3 group (p=0.01). MACE occurred 45.7% in low FT3 group and 18.6%in normal FT3 group (p=0.001). The mortality in patients with cardiogenic shock was 43.3% compared to 3.6% in patients without cardiogenic shock. Multivariate logistic regression analysis showed FT3 level was an important predictor for cardiogenic shock in patients hospitalized with STEMI (p=0.01).

Conclusion: Low FT3 levels were strongly associated with cardiogenic shock in patients with STEMI. The FT3 level screening may be a simple and valuable way to predict Cardiogenic shock after STEMI.

Bangladesh Heart Journal 2023; 38(1): 1-7

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Published

2023-07-08

How to Cite

Huda, S. M. N. ., Choudhury, A. K., Jahan, J., Tabassum, M. ., Rahman, A., & Debnath, D. D. . (2023). Association of free Tri-iodothyronine Level with Cardiogenic Shock and Prognosis in Patients Hospitalized with Acute STelevation Myocardial Infarction Treated with Streptokinase Therapy. Bangladesh Heart Journal, 38(1), 1–7. https://doi.org/10.3329/bhj.v38i1.67187

Issue

Vol. 38 No. 1 (2023)

Section

Original Articles

License

Copyright (c) 2023 Bangladesh Cardiac Society

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Articles in the Bangladesh Heart Journal are Open Access articles published under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).  This license permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.