Clinical and Biochemical Assessment of Hypogonadism in Type 2 Diabetic Men

Authors

  • SK Talukder Department of Endocrinology, Rangpur Medical College
  • F Afsana Department of Endocrinology, BIRDEM, Dhaka
  • ZA Latif Department of Endocrinology, BIRDEM, Dhaka
  • F Pathan Department of Endocrinology, BIRDEM, Dhaka
  • SM Ashrafuzzaman Department of Endocrinology, BIRDEM, Dhaka
  • SJ Khan Department of Endocrinology, Enam Medical College, Savar
  • SH Habib Health Economics Unit, BADAS, Dhaka
  • S Saha Health Economics Unit, BADAS, Dhaka

DOI:

https://doi.org/10.3329/birdem.v1i1.12378

Keywords:

Hypogonadism, Metabolic syndrome, Diabetes Mellitus

Abstract

doi

Aim: The aim of the study was to assess the prevalence of clinical hypogonadism in type 2 diabetic men based on clinical features and available biochemical measures.

Materials and Methods: In this study carried out in a tertiary level hospital, serum concentration of total testosterone was measured in 170 type 2 diabetic (mean age 44.9±7.9 years) subjects who have erectile dysfunction or other features of hypogonadism.

Results: The mean total testosterone concentration in type 2 diabetic men was 14.4±5.6 nmol/l. Fifty nine of 170 (34.7%) type 2 diabetic subjects had low serum testosterone levels (d12 nmol/L). Luteinizing hormone (LH) and follicle stimulating hormone (FSH) concentrations in type 2 diabetic men were inappropriately low with a very high prevalence of hypogonadotropic hypogonadism. BMI and waist circumference were both negatively correlated with testosterone levels, with the association being stronger for waist circumference. HbA1C level also reveal a negative association with sexual dysfunction and hypogonadotropic hypogonadism among type 2 diabetic men. Metabolic syndrome is also associated with the low serum testosterone levels in the study subjects.

Conclusions: This study reveals that serum total testosterone levels are lower in diabetic men with signs/symptoms of hypogonadism. Hypogonadotropic hypogonadism is frequent in diabetic hypogondal population. There is an association between poor glycaemic control and hypogonadism in male diabetic persons.

DOI: http://dx.doi.org/10.3329/birdem.v1i1.12378

Birdem Med J 2011; 1(1): 3-9

Downloads

Download data is not yet available.
Abstract
714
PDF
471

Downloads

Published

2012-10-25

How to Cite

Talukder, S., Afsana, F., Latif, Z., Pathan, F., Ashrafuzzaman, S., Khan, S., Habib, S., & Saha, S. (2012). Clinical and Biochemical Assessment of Hypogonadism in Type 2 Diabetic Men. BIRDEM Medical Journal, 1(1), 3–9. https://doi.org/10.3329/birdem.v1i1.12378

Issue

Section

Original Articles