Haemodynamic Response After induction of Anaesthesia in Patients undergoing Coronary Artery Bypass Grafting Surgery of Poor Left ventricular Function. A comparison between Thiopental / fentanyl and Etomidate / fentanyl

Authors

  • Md. Hamidur Rahman Department of Cardiac Anaesthesia, Ibrahim Cardiac Hospital & Research Institute, Sahabagh, Dhaka 1000
  • Bhabesh Chandra Mondal Department of Cardiac Anaesthesia, Square Hospital, Dhaka
  • Niaz Ahmed Department of Cardiothoracic Anaesthesia & ICU, Apollo Hospital, Dhaka
  • Md. Sirajul Islam Department of Cardiac Anaesthesia, Ibrahim Cardiac Hospital & Research Institute
  • ZA Faruquee Department of Cardiac Anaesthesia, Ibrahim Cardiac Hospital & Research Institute

DOI:

https://doi.org/10.3329/birdem.v3i1.17123

Keywords:

Induction, Thiopental, Etomidate, Fentanyl, CABG Surgery, Left ventricular dysfunction

Abstract

Objective: To compare the haemodynamic effect of thiopental/fentanyl with etomidate/fentanyl during anaesthetic induction in patients with coronary artery disease with poor left ventricular function (ejection fraction < 45%).

Design: A retrospective randomized trial. Setting: Ibrahim Cardiac Hospital and Research Institute. Participants: Twenty patients with coronary artery disease of poor left ventricular function (ejection fraction<45%) scheduled for elective coronary artery bypass surgery. Interventions: Patients were allocated randomly to receive either thiopental/fentanyl or etomidate/fentanyl for induction.

Measurement & Main Results: Haemodynamic response (heart rate, mean arterial pressure) were recorded at 1 minute interval starting from induction till five minutes after intubations. The reduction of mean arterial pressure was greater in patients who received thiopental/fentanyl induction (maximal decrease 32%) in comparison to etomidate/fentanyl induction (maximal decrease12%) [P<0.05 which is statistically significant]. The changes of heart rate were insignificant between the groups (reduction of heart rate 8% versus 7%).

Conclusion: Etomidate/ fentanyl induction reduces less blood pressure in comparison to thiopental/fentanyl induction in patients of poor left ventricular function but changes of heart rate were insignificant in between the groups.

Birdem Med J 2013; 3(1): 23-26

DOI: http://dx.doi.org/10.3329/birdem.v3i1.17123

Downloads

Download data is not yet available.
Abstract
756
PDF
446

Downloads

Published

2013-11-24

How to Cite

Rahman, M. H., Mondal, B. C., Ahmed, N., Islam, M. S., & Faruquee, Z. (2013). Haemodynamic Response After induction of Anaesthesia in Patients undergoing Coronary Artery Bypass Grafting Surgery of Poor Left ventricular Function. A comparison between Thiopental / fentanyl and Etomidate / fentanyl. BIRDEM Medical Journal, 3(1), 23–26. https://doi.org/10.3329/birdem.v3i1.17123

Issue

Section

Original Articles