Aetiology of Asymptomatic Raised Serum Alanine Aminotransferase in Patients with Type 2 Diabetes Mellitus

Authors

  • Hasna Fahmima Haque Department of Medicine, BIRDEM General Hospital and Ibrahim Medical College, Dhaka
  • Farhana Afroz Department of Medicine, BIRDEM General Hospital and Ibrahim Medical College, Dhaka
  • Samira Rahat Afroze Registrar, BIRDEM General Hospital and Ibrahim Medical College, Dhaka
  • Jamal Uddin Ahmed Assistant Professor, Department of Medicine, BIRDEM General Hospital and Ibrahim Medical College, Dhaka
  • AKM Shaheen Ahmed Department of Medicine, BIRDEM General Hospital and Ibrahim Medical College, Dhaka
  • Md Delwar Hossain Department of Medicine, BIRDEM General Hospital and Ibrahim Medical College, Dhaka
  • Md Raziur Rahman Associate Professor, Department of Medicine, BIRDEM General Hospital and Ibrahim Medical College, Dhaka
  • AKM Musa Department of Medicine, BIRDEM General Hospital and Ibrahim Medical College, Dhaka
  • Khwaja Nazim Uddin Department of Medicine, BIRDEM General Hospital and Ibrahim Medical College, Dhaka
  • Muhammad Abdur Rahim Assistant Professor, Department of Nephrology, BIRDEM General Hospital, Dhaka
  • Palash Mitra Assistant Registrar, Department of Nephrology, BIRDEM General Hospital, Dhaka
  • Gaffar Amin Assistant Professor, Department of Cardiology, Dhaka Medical college, Dhaka

DOI:

https://doi.org/10.3329/birdem.v6i1.28408

Keywords:

alanine aminotransferase, asymptomatic, type 2 diabetes mellitus, non-alcoholic fatty liver disease.

Abstract

Background: Elevated level of serum alanine aminotransferase (ALT) is not uncommon in routine laboratory test. This study was aimed to find out the aetiology of asymptomatic raised ALT in hospitalized type 2 diabetes mellitus (T2DM) patients

 Methods: This cross-sectional study was done in BIRDEM over a period of six month. T2DM patients having asymptomatic raised serum ALT were evaluated clinically and by laboratory tests.

Results: Total number of patients was 53. Among them male were 39 and female were 14. Male and female ratio was 2.8:1. Mean age was 49.2±7.9 years. Mean body mass index (BMI) was 25.5±5 kg/m2. Among the study subjects, 25 (47.2%) were overweight and 16 (30.2%) were obese. Hypertension, hepatomegaly and dyslipidaemia were present in 29 (54.7%), 11 (20.8%) and 36 (67.96%) cases respectively. Non-alcoholic fatty liver disease (NFALD) was the commonest (37, 69.8%) aetiology for raised ALT in this study. Seropositivity for hepatitis B virus (HBV) surface antigen (HBsAg) and antibody against hepatitis C virus (anti-HCV) were present in 7 and 5 cases respectively. In 4 cases cause could not be identified. Most of the cases with >5 times raised ALT had hepatitis B or C infection.

Conclusion: Elevation of serum ALT is common in T2DM patients. NAFLD is the commonest cause followed by hepatitis B and C virus infection.

Birdem Med J 2016; 6(1): 32-35

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Author Biography

Hasna Fahmima Haque, Department of Medicine, BIRDEM General Hospital and Ibrahim Medical College, Dhaka



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Published

2016-06-25

How to Cite

Haque, H. F., Afroz, F., Afroze, S. R., Ahmed, J. U., Ahmed, A. S., Hossain, M. D., Rahman, M. R., Musa, A., Uddin, K. N., Rahim, M. A., Mitra, P., & Amin, G. (2016). Aetiology of Asymptomatic Raised Serum Alanine Aminotransferase in Patients with Type 2 Diabetes Mellitus. BIRDEM Medical Journal, 6(1), 32–35. https://doi.org/10.3329/birdem.v6i1.28408

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Original Articles