Swyer syndrome: Reports of 2 cases

Authors

  • Tanzeem S Chowdhury Assistant Professor, Dept. of Obstetrics and Gynecology, BIRDEM General Hospital, Dhaka
  • Umme Ruman Classified specialist, Dept. of Obstetrics and Gynecology, Dhaka CMH, Dhaka
  • TA Chowdhury Chief Consultant, Dept. of Obstetrics and Gynecology, BIRDEM General Hospital, Dhaka

DOI:

https://doi.org/10.3329/birdem.v6i1.28413

Keywords:

Swyer syndrome, gonodal dysgenesis, SRY gene

Abstract

Swyer syndrome is a form of pure 46 XY gonodal dysgenesis in which individuals have male chromosomal pattern (46XY) but a female phenotype. One out of five women with the Swyer syndrome have a deletion in the DNA-binding region of the SRY gene, while in the remaining 8090% of cases, the SRY gene is normal and mutations in other testis determining factors are probably implicated. Early diagnosis is crucial for a number of reasons: first, the risk of gonadal malignancy, second, the early institution of estrogen therapy for induction of puberty and third, to allow for adequate hormone replacement to improve bone mineral density. We present two cases of Swyer syndrome with different presentation

Birdem Med J 2016; 6(1): 50-53

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Author Biography

Tanzeem S Chowdhury, Assistant Professor, Dept. of Obstetrics and Gynecology, BIRDEM General Hospital, Dhaka



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Published

2016-06-25

How to Cite

Chowdhury, T. S., Ruman, U., & Chowdhury, T. (2016). Swyer syndrome: Reports of 2 cases. BIRDEM Medical Journal, 6(1), 50–53. https://doi.org/10.3329/birdem.v6i1.28413

Issue

Section

Case Reports