Unilateral nodular adrenocortical hyperplasia presenting as Cushing’s syndrome: a case report

Authors

  • Lubna Naznin Classified Specialist in Pathology (Biochemistry), Armed Forces Institute of Pathology, Dhaka Cantonment, Bangladesh
  • Susane Giti Classified Specialist in Pathology (Hematology), Commandant, Armed Forces Institute of Pathology, Dhaka Cantonment, Bangladesh
  • SK Md Jaynul Islam Classified Specialist in Pathology (Histopathology) and Project Director of AFIP Modernization Project, Armed Forces Institute of Pathology, Dhaka Cantonment, Bangladesh
  • Khandaker Rokshana Akhter Classified Specialist in Pathology , (Biochemistry), Armed Forces Medical College, Dhaka Cantonment, Bangladesh
  • Shamoli Yasmin Classified Specialist in Pathology (Histopathology), Armed Forces Institute of Pathology, Dhaka Cantonment, Bangladesh
  • Md Rafiqul Islam Graded Specialist in Pathology, Armed Forces Institute of Pathology, Dhaka Cantonment, Bangladesh

DOI:

https://doi.org/10.3329/birdem.v12i1.57231

Keywords:

Cushing syndrome, Hyperaldosteronism, Nodular adrenocortical hyperplasia

Abstract

Cushing syndrome results from chronic exposure to excess cortisol. Nodular adrenal hyperplasia is usually bilateral and has only a few case reports of unilateral presentation. Biochemically it is presented as hyperaldosteronism or as Cushing’s syndrome. Here, we are reporting a 17-year-old female presenting with weight gain over 5 months and uncontrolled hypertension. Biochemically she was found to have diabetes mellitus, secondary hypothyroidism and hypogonadotrophic hypogonadism due to Cushing’s syndrome of adrenal origin. Unilateral adrenal adenoma/hyperplasia in right adrenal gland was evident by radiology. Histopathological examination was done after laparoscopic adrenalectomy showed nodular adrenocortical hyperplasia in right adrenal mass. Following surgery, clinical features of the patient improved notably. Cushing syndrome due to unilateral nodular adrenocortical hyperplasia is a rare entity. Biochemical evaluation of hypothalamo-pituitary-adrenal axis, radiological evidence and histopathology are the important armaments can guide to final diagnosis.

BIRDEM Med J 2022; 12(1): 78-82

Downloads

Download data is not yet available.
Abstract
32
PDF
33

Downloads

Published

2021-12-30

How to Cite

Naznin, L. ., Giti, S. ., Islam, S. M. J. ., Akhter, K. R. ., Yasmin, S. ., & Islam, M. R. . (2021). Unilateral nodular adrenocortical hyperplasia presenting as Cushing’s syndrome: a case report. BIRDEM Medical Journal, 12(1), 78–82. https://doi.org/10.3329/birdem.v12i1.57231

Issue

Section

Case Reports