A case of premature aging with recurrent pancreatitis and lipodystrophy

Authors

  • Mita Dutta MD Phase-B Resident, Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh
  • Maliha Tabassum MD Phase-B Resident, Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh
  • Mohammad Aminul Islam MD Phase-B Resident, Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh
  • Kazi Nazmul Hossain Assistant Professor, Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh
  • Faria Afsana Associate Professor, Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh.
  • Mohammod Feroz Amin Professor, Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh
  • Md Faruque Pathan Professor, Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh
  • Md Faruque Pathan Professor, Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/birdem.v13i1.63900

Keywords:

Werner’s syndrome, pancreatitis, hypertriglyceridemia, autoimmune polyglandular syndrome, type B insulin resistance syndrome.

Abstract

Werner’s syndrome (WS) is characterized by insulin resistance along with signs of premature aging. It poses great diagnostic challenge because of its unusual presentation. We describe a case of WS in a 30-year-old female, who presented with recurrent pancreatitis and documented hypertriglyceridemia along with hyperglycemia despite getting more than 200 units of insulin per day, without any history of hyperglycemic emergency such as diabetic ketoacidosis (DKA)/ hyperglycemic hyperosmolar state (HHS). Examination showed signs of premature aging (alopecia, progressive sharpening of facial features, loss of upper incisor teeth, wrinkles and freckles) and generalized wasting. Scalp biopsy confirmed the diagnosis.

BIRDEM Med J 2023; 13(1): 56-59

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Published

2023-01-12

How to Cite

Dutta, M. ., Tabassum, M., Islam, M. A. ., Hossain, K. N. ., Afsana, F. ., Amin, M. F. ., Pathan, M. F. ., & Pathan, M. F. . (2023). A case of premature aging with recurrent pancreatitis and lipodystrophy. BIRDEM Medical Journal, 13(1), 56–59. https://doi.org/10.3329/birdem.v13i1.63900

Issue

Vol. 13 No. 1 (2023)

Section

Case Reports