TY - JOUR AU - Saha, Rama AU - Choudhury, SAR PY - 2010/09/19 Y2 - 2024/03/28 TI - Gentamicin Induced Nephrotoxicity in Long Evans Rat - An Experimental Study JF - Bangladesh Journal of Anatomy JA - Bangla. J. Anat. VL - 7 IS - 2 SE - Articles DO - 10.3329/bja.v7i2.6088 UR - https://banglajol.info/index.php/BJA/article/view/6088 SP - 84-86 AB - <p><strong>Context: </strong>Gentamicin is an antibiotic used in gram-negative infection. It is an nephrotoxic agent. Proximal tubular epithelial cells are selectively sensitive to gentamicin.</p> <p><strong>Objective: </strong>To observe the toxic effect of gentamicin on epithelial cells of proximal convoluted tubule in Long Evans rats.</p> <p><strong>Study design: </strong>An experimental study.</p> <p><strong>Plan and period of study: </strong>The study was carried out in the Department of Pharmacology of IPGMR Dhaka during the period of 1995 to 1996.</p> <p><strong>Materials and methods: </strong>Eighteen mature long Evans rats were divided into three groups A, B &amp; C. The rats of group A were treated with vehicle and group B and C were treated with gentamicin 50gm and 100gm respectively. Blood urea and serum creatinine were measured and microscopic damaged cells were counted.</p> <p><strong>Result: </strong>There was significant increase in serum creatinin and blood urea in gentamicin treated groups. Microscopic examination of kidney showed necrosis of proximal tubular cells.</p> <p><strong>Conclusion: </strong>It can be concluded from this study that gentamicin has toxic effects on renal tubule.</p> <p><strong>Key words: </strong>Gentamicin.</p> <p>DOI: 10.3329/bja.v7i2.6088<strong> </strong></p> <p>Bangladesh J. Anat. 2009; 7(2) :84-86</p> ER -