Platelet Indices As Markers For Remission In ALL During Induction of Remission: An Experience of 52 Cases

Authors

  • Masuma Khan Assistant Professor, Department of Paediatrics, Ad-din women’s Medical College Hospital, Dhaka, Bangladesh
  • AKM Amirul Morshed Professor & Head, Department of Paediatric Hematology & Oncology, Dhaka Medical College Hospital, Dhaka, Bangladesh
  • Taslim Uddin Ahmed Professor, Department of Paediatrics, Ad-din women’s Medical College Hospital, Dhaka, Bangladesh
  • Hakimul Haque Khan Associate Professor, Department of Paediatrics, Ad-din women’s Medical College Hospital, Dhaka, Bangladesh
  • Ashraf Uddin Ahmed Professor, Department of Paediatrics, Ad-din women’s Medical College Hospital, Dhaka, Bangladesh
  • Sudipta Roy Assistant Professor, Department of Paediatrics, Ad-din women’s Medical College Hospital, Dhaka, Bangladesh
  • ARM Luthful Kabir Professor, Department of Paediatrics, Ad-din women’s Medical College Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjch.v44i1.49685

Keywords:

Platelet Indices, ALL (Acute Lymphoblastic Leukemia), markers of induction of remission

Abstract

Background: Platelet indices (plateletcrit, mean platelet volume, platelet distribution width and Platelet count) are potentially useful markers for the early diagnosis and outcome of many diseases. Platelet indices could serve as surrogate marker for remission in patients with ALL.

Objective: To observe change of platelet indices in ALL during induction of remission.

Material & Methods: This observational study was carried out with 52 newly diagnosed ALL patients ranging from 1.5 to 12 years admitted at DMCH, from January to December 2015. Platelet indices such as plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PLT) were monitored from admission to induction of remission phase of chemotherapy and were analyzed.

Result: Mean PLT was found 93442.3±29966.4 cmm before treatment, 137442.3±27217.9 cmm in 1st week and 231653.8±42543.5 cmm in 4th week. Mean PCT was found 0.09±0.11% before treatment, 0.16±0.11% in 1st week and 0.25±0.18 % in 4th week. Both PLT & PCT was increased significantly during induction of remission after one and four weeks. Mean PDW was found 13.1±3.9 fl before treatment, 12.9±3.5 fl in 1st week and 12.0±3.1 fl in 4th week. MPV was found 10.6±2.1 fl before treatment, 11.0±1.4 fl in 1st week and 10.7±1.4 fl in 4th week. The change of MPV & PDW were not statistically significant when compared with that of before treatment.

Conclusion: It can be concluded that among four important platelet indices, PLT and PCT were significantly associated with remission in ALL during induction of remission.

Bangladesh J Child Health 2020; VOL 44 (1) :34-39

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Published

2020-10-12

How to Cite

Khan, M., Morshed, A. A., Ahmed, T. U., Khan, H. H., Ahmed, A. U., Roy, S., & Kabir, A. L. (2020). Platelet Indices As Markers For Remission In ALL During Induction of Remission: An Experience of 52 Cases. Bangladesh Journal of Child Health, 44(1), 34–39. https://doi.org/10.3329/bjch.v44i1.49685

Issue

Vol. 44 No. 1 (2020)

Section

Original Articles