Liver Function Derangement and Bleeding Morbidity in Dengue Fever and Dengue Haemorrhagic Fever in a tertiary Hospital in Bangladesh

Authors

  • Md Arifuzzaman Junior Consultant, Department of Medicine, Sir Salimullah Medical College,Mitford Hospital, Dhaka
  • - Amiruzzaman Associate Professor, Department of Medicine, Sir Salimullah Medical College,Mitford Hospital, Dhaka
  • Md Saddam Hossain Registrar,Department of Medicine, Sir Salimullah Medical College,Mitford Hospital, Dhaka
  • Naylla Islam Indoor Medical officer, Department of Medicine, Sir Salimullah Medical College,Mitford Hospital, Dhaka
  • Abdullah Al Noman Indoor Medical officer,Department of Medicine, Sir Salimullah Medical College,Mitford Hospital, Dhaka
  • Bhabananda Baroi Indoor Medical officer, Department of Medicine, Sir Salimullah Medical College, Mitford Hospital, Dhaka
  • TM Shahanawaz Islam Registrar,Department of Haematology, Sir Salimullah Medical College,Mitford Hospital, Dhaka
  • Goutam Chandra Bhowmik Assistant Registrar, National Institute of Cardiovascular Diseases Dhaka, Bangladesh
  • Masud ur Rahman Assistant Registrar, Department of Medicine, Sir Salimullah Medical College,Mitford Hospital, Dhaka

DOI:

https://doi.org/10.3329/bjm.v33i1.56789

Keywords:

Medicine, Haematology

Abstract

Background: Dengue is a major international health concern that is prevalent in tropical and sub tropical countries. Study of dengue infection and its Liver complications are scarce from countries like India. This study was done to assess the frequency and spectrum of liver dysfunction and bleeding morbidity in Dengue infection patients.

Methods: A Cross sectional prospective observational study was performed in the of Department of Medicine Sir Salimullah Medical College Mitford Hospital. All the inpatients who were diagnosed with dengue infection between July 2015 to July 2016 were included in this study. A total of 70 patients were included in the study.

Results: Patients were classified as classical dengue fever (DF) 61.5.% dengue haemorrhagic fever (DHF) 38.5%. The mean age was 28.607±10.45 years in DF group and 26.78±11.78 years in DHF group and male: female ratio was 3:1. Deranged serum glutamic-oxaloacetic transaminase (SGOT) and/or Serum glutamic pyruvic transaminase (SGPT) was present in most of the patients. Elevation of ALT level occured more in DHF group patient (81%) than DF group (46%). Out of 70 patient 28(40%) patient were within normal value. 42 (60%) patient had elevated ALT level which is statistically significant (p value-<0.05)..The degree of rise of SGOT, SGPT,and Bilirubin was significantly more in DHF and DSS, as compared to DF. About bleeding morbidity, purpura was a mentionable finding 29(41%) but gum bleeding 15(21%), echymosis 14(20%), are less in both DF and DHF group. Major bleeding like hematomesis 5 (7%), melaena 4 (5%) and haematuria 1 (1%) also occured in both group of patients.

Conclusion: Liver dysfunction in the form of raised SGPT was seen in almost all patients. Preferentially high SGOT may serve as an early indicator of dengue infection while high values of bilirubin, SGOT, SGPT,may be an indicator of severe disease and poor prognosis.

Bangladesh J Medicine July 2022; 33(1) : 44-51

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Published

2021-12-06

How to Cite

Arifuzzaman, M., Amiruzzaman, .-., Hossain, M. S. ., Islam, N., Noman, A. A. ., Baroi, B. ., Islam, T. S., Bhowmik, G. C., & Rahman, M. ur. (2021). Liver Function Derangement and Bleeding Morbidity in Dengue Fever and Dengue Haemorrhagic Fever in a tertiary Hospital in Bangladesh. Bangladesh Journal of Medicine, 33(1), 44–51. https://doi.org/10.3329/bjm.v33i1.56789

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Section

Original Articles