Relationship between Plasma N-Terminal Pro-Brain Natriuretic Peptide Levels With Clinical Presentations and Short Term Functional Outcome in Acute Ischemic Stroke Patients

Authors

  • Aminur Rahman Professor, Department of Neurology, Sir Salimullah Medical College, Mitford, Dhaka, Bangladesh. https://orcid.org/0000-0001-9261-7734
  • Mahbubul Hakim Mishu Resident, Department of Neurology, Sir Salimullah Medical College Mitford Hospital Dhaka, Bangladesh

Keywords:

Acute Ischemic Stroke, N-terminal pro-brain natriuretic peptide (NT-proBNP), Oxfordshire community stroke project (OCSP), Modified Rankin Scale (mRS)

Abstract

Background: Since elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels are a crucial biomarker for determining stroke etiology and forecasting both immediate severity and short-term functional outcomes, the association between N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and Acute Ischemic Stroke (AIS) has attracted substantial clinical attention.The goal of this study was to determine the association between NT-proBNP levels and acute ischemic stroke patients, which may aid in the patients' diagnosis and severity evaluation. Methods: This case-control study was conducted in the department of Neurology, Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh from November, 2023 to October; 2024.Total 100 subjects were enrolled in this study. Among this, 50acuteischemicstrokepatients with history within 3 days and confirmed by CT scan of head or MRI of brain were selected purposively from the Neurology department and Internal Medicine Department of  Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh. Another 50 age and gender matched subjects were selected from these facilities for comparison. Venous blood samples were collected from these patients and analyzed for estimation of plasma NT-proBNP. Results: This study found Mean plasma NT-proBNP level was significantly higher (333.0±221.9pg/ml) in acute ischemic stroke patients (Case group) than control group (109.4±131.1pg/ml). Mean plasma NT- proBNP level for different anatomical sites across the OCSP classification showed significantly higher value in total anterior circulation stroke (435.7±217.2pg/ml). Mean plasma NT- proBNP level according to TOAST classification showed significantly higher value in Cardioembolic types (435.7±217.2pg/ml).A moderately strong positive correlation was observed between plasma NT-proBNP level   score at admission (r=0.566;p<0.001) and after 3months (r=0.540;p =0.003).A moderately strong positive correlation was found between plasma NT-proBNP level and mRS score at admission (r = 0.507; p <0.001) and after 3months (r=0.420;p=0.002). Conclusion: Plasma NT-Pro BNP levels were significantly connected with acute ischemic stroke, as well as with severity and prognosis. It identifies plasma NT-proBNP as a significant marker for the diagnosis and severity assessment of acute ischemic stroke.

Bangladesh J Medicine 2026; Vol. 37, No. 2(1) Supplementation: 204

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Author Biography

Aminur Rahman, Professor, Department of Neurology, Sir Salimullah Medical College, Mitford, Dhaka, Bangladesh.

Prof. Dr. Aminur Rahman is now working as Professor and Head, Department of Neurology, Sir Salimullah Medical College, Dhaka, Bangladesh. He graduated from Sylhet M.A.G. Osmani Medical College under the University of Chittagong, Bangladesh, in 1998. He has completed his MD in Neurology from the University of Dhaka and his FCPS in Internal Medicine from the Bangladesh College of Physicians and Surgeons (BCPS), Dhaka. He has been awarded the FRCP (Edinburgh), UK. He has also been honored as a Fellow of the ACP (FACP). He achieved his fellowship in Interventional Neuroradiology (FINR) from the University Hospital of Zurich, Switzerland, and also trained at Ramathibodi Hospital, Mahidol University, Thailand. Recently, in 2024, he has been awarded an Honorary Fellowship by the Indian College of Physicians (FICP).

He is now working as Editor-in-Chief of the Bangladesh Journal of Medicine (BJM), Joint Editor-in-Chief of the Journal of the Bangladesh College of Physicians and Surgeons (JBCPS), and Editor of the Bangladesh Journal of Neurosciences (BJN). He is also serving as an International Editorial Board Member of the Journal of the Indian Medical Association (JIMA) and the Journal of Neurology and Neurorehabilitation Research (JNNR), UK. He has published more than 77 research papers in reputed journals, both national and international. He is also the author of four textbooks: “Basics of EEG—1st ed. (2024)”; “Short Cases in Clinical Neurology—3rd ed. (2024)”; “Neuroimaging in Clinical Practice—2nd ed. (2022)”; and “Fundamentals in Clinical Neurology—2nd ed. (2023),” which were published in India and Bangladesh.

He is a medical scientist and received research grants for research projects six times from the Ministry of Science and Technology, Bangladesh. He is a member of the Institutional Review Board (IRB) of Sir Salimullah Medical College, Mitford, Dhaka, Bangladesh. He attended different national and international seminars and symposiums in medicine and neurology and interventional neuroradiology in Bangladesh, Switzerland, Thailand, Malaysia, USA, Canada, India, UAE. Australia as faculty and resource persons.

 

He is a regular examiner of the different universities of Bangladesh as a clinical examiner of undergraduate students of MBBS under Dhaka University (DU) of Bangladesh, FCPS (Medicine) of Bangladesh College of Physicians and Surgeons (BCPS) and MD Neurology under Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh, and MRCP (PACES), UK. 

I am Prof. Dr. Aminur Rahman, now working as a professor and head of the Department of Neurology at Sir Salimullah Medical College, Dhaka, Bangladesh. I graduated from Sylhet M.A.G. Osmani Medical College at the University of Chittagong, Bangladesh, in 1998. I have completed my MD in Neurology from the University of Dhaka and my FCPS in Internal Medicine from the Bangladesh College of Physicians and Surgeons (BCPS), Dhaka. I have been awarded the FRCP (Edinburgh), UK. I have also been honored as a Fellow of the ACP (FACP). He achieved his fellowship in Interventional Neuroradiology (FINR) from the University Hospital of Zurich, Switzerland, and also trained at Ramathibodi Hospital, Mahidol University, Thailand. Recently, in 2024, he was awarded an Honorary Fellowship by the Indian College of Physicians (FICP).

I am now working as Deputy Executive Editor of the Bangladesh Journal of Medicine (BJM), Joint Editor in Chief Journal of the Bangladesh College of Physicians and Surgeons (JBCPS), and Editor of the Bangladesh Journal of Neurosciences (BJN). He is also serving as an International Editorial Board Member of the Journal of the Indian Medical Association (JIMA) and the Journal of Neurology and Neurorehabilitation Research (JNNR), UK. He has published more than 65 research papers in reputed journals, both national and international. He is also the author of four textbooks: “Basics of EEG—1st ed. (2024)”; “Short Cases in Clinical Neurology—3rd ed. (2024)”; “Neuroimaging in Clinical Practice—2nd ed. (2022)”; and “Fundamentals in Clinical Neurology—2nded. (2023),” which are published in India and Bangladesh.

I am a medical scientist and received research grants for research projects six times from the Ministry of Science and Technology, Bangladesh. He is a member of the Institutional Review Board (IRB) of Sir Salimullah Medical College, Mitford, Dhaka, Bangladesh. I have attended different national and international seminars and symposiums in medicine, neurology, and interventional neuroradiology in Bangladesh, Switzerland, Thailand, Malaysia, USA, Canada, India, and the UAE. Australia as faculty and resource person.

I am a regular examiner of the different universities of Bangladesh as a clinical examiner of undergraduate students of MBBS under Dhaka University (DU) of Bangladesh, FCPS (Medicine) of Bangladesh College of Physicians and Surgeons (BCPS), and MD Neurology under Bangladesh Medical University (BMU), Bangladesh,, and MRCP (PACES), UK.

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Published

2026-07-26

How to Cite

Rahman, A., & Mishu, M. H. (2026). Relationship between Plasma N-Terminal Pro-Brain Natriuretic Peptide Levels With Clinical Presentations and Short Term Functional Outcome in Acute Ischemic Stroke Patients. Bangladesh Journal of Medicine, 37(20), 204. https://doi.org/10.3329/bjm.v37i20.89325

Issue

Vol. 37 No. 2 (Supplement, May 2026)

Section

Scientific Presentation

How to Cite

Rahman, A., & Mishu, M. H. (2026). Relationship between Plasma N-Terminal Pro-Brain Natriuretic Peptide Levels With Clinical Presentations and Short Term Functional Outcome in Acute Ischemic Stroke Patients. Bangladesh Journal of Medicine, 37(20), 204. https://doi.org/10.3329/bjm.v37i20.89325