Determination of minimum inhibitory concentration of Azithromycin, Ofloxacin and Ceftriaxone in Ciprofloxacin resistant Salmonella causing enteric fever

Authors

  • Shamima Kawser Department of Microbiology,Delta Medical College, Mirpur-1, Dhaka
  • Md. Ruhul Amin Miah Department of Microbiology & Immunology, BSMMU, Shahbag, Dhaka
  • Ahmed Abu Saleh Department of Microbiology & Immunology, BSMMU, Shahbag, Dhaka
  • Khandker Md. Nurus Sabah Department of Cardiology, Dhaka Medical College, Dhaka
  • Tanzima Begum Department of Pharmacology & Therapeutics, Delta Medical College, Mirpur-1, Dhaka

DOI:

https://doi.org/10.3329/bjmm.v5i1.15818

Keywords:

Salmonella, Minimum inhibitory concentration, Multi drug resistant Salmonella

Abstract

The therapeutic alternatives available for use against ciprofloxacin resistant enteric fever isolates in an endemic area are limited. The antibiotics currently available are the quinolones, third-generation cephalosporins and azithromycin. In this study, the MICs of various drugs were determined for 100 enteric fever isolates (72 Salmonella enterica serovar typhi and 28 Salmonella enterica serovar paratyphi A ). Ciprofloxacin resistant (1oo%) Salmonella strains were sensitive to ofloxacin and ceftriaxone showing MICs of 0.0078-2 g /ml and 0.0156-2g /ml respectively. Salmonella strains (98%) had MIC values 1-32 g /ml for azithromycin. These results indicate that ofloxacin and ceftriaxone may be convenient alternative antimicrobial agents for Salmonella isolates.

DOI: http://dx.doi.org/10.3329/bjmm.v5i1.15818

Bangladesh J Med Microbiol 2011; 05 (01): 26-30

 

 

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Published

2013-07-24

How to Cite

Kawser, S., Miah, M. R. A., Saleh, A. A., Sabah, K. M. N., & Begum, T. (2013). Determination of minimum inhibitory concentration of Azithromycin, Ofloxacin and Ceftriaxone in Ciprofloxacin resistant Salmonella causing enteric fever. Bangladesh Journal of Medical Microbiology, 5(1), 26–30. https://doi.org/10.3329/bjmm.v5i1.15818

Issue

Vol. 5 No. 1 (2011)

Section

Original Articles