Association of HLA -A1 and HLA -B8 Antigens with Natural Rubella Infection in Bangladeshi Females

Authors

  • B Afzalunnessa Assistant Professor, Department of Virology BSMMU, Shabagh, Dhaka
  • Shahina Tabassum Department of Virology, BSMMU, Shabagh, Dhaka
  • Saifullah Munshi Assistant Professor, Department of Virology BSMMU, Shabagh, Dhaka
  • Md. Nazrul Islam Department of Virology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

DOI:

https://doi.org/10.3329/bjmm.v1i1.20489

Keywords:

HLA, Rubella specific immunoglobulin, antigens

Abstract

HLA typing was carried out for HLA -A1 and HLA -B8 antigens among 40 Rubella specific immunoglobulin G (RSIgG) positive and 10 RSIgG negative subjects by employing microlympohocytotoxicity technique in viable (>85%) lymphocytes separated from fresh blood. Among these, HLA-A1 antigen was detected in 20 (50%) of RSIgG positive and 4 (40%) of RSIgG negative subjects. The HLA-B8 antigen was detected in 1 (2.5%) of RSIgG positive and in none of the RSIgG negative subjects. None of the subjects had both A1 and B8 antigens. Of the total subjects tested, 24 (48%) were positive for A1 antigen but only 1 (2.0%) was found positive for B8 antigen. In conclusion, HLA -A1 antigen was more frequently found in local population than B8 antigen. However, in this study, a positive correlation of A1 and B8 antigens with natural rubella infection could not be established.

Bangladesh J Med Microbiol 2007;01(01):13-16

 

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Published

2016-05-25

How to Cite

Afzalunnessa, B., Tabassum, S., Munshi, S., & Islam, M. N. (2016). Association of HLA -A1 and HLA -B8 Antigens with Natural Rubella Infection in Bangladeshi Females. Bangladesh Journal of Medical Microbiology, 1(1), 13–16. https://doi.org/10.3329/bjmm.v1i1.20489

Issue

Vol. 1 No. 1 (2007)

Section

Original Articles