Drug Resistance Pattern of <i>Mycobacterium tuberculosis</i> Isolated from Patients Attending a Referral Hospital

Authors

  • ABM Abdul Wadud Department of Microbiology & Immunology, LABAID LTD, Dhaka
  • ASM Matiur Rahman Armed Forces Institute of Pathology, Dhaka Cantonment
  • Md Ruhul Amin Miah Dept of Microbiology & Immunology, BSMMU, Dhaka
  • Ahmed Abu Saleh Dept of Microbiology & Immunology, BSMMU, Dhaka

DOI:

https://doi.org/10.3329/bjmm.v3i2.5321

Keywords:

Mycobacterium tuberculosis

Abstract

This study was carried out to isolate M. tuberculosis from smear positive sputum samples by MB/BacT automated culture system and investigate the drug resistance pattern. Among 101 smear positive cases 96 (95.05 %) yielded growth of Mycobacteria, 3 (02.97 %) were contaminated and 2 (01.98 %) showed no growth. Culture positive detection time for M. tuberculosis was lowest 7 days and highest 36.3 days and average detection time was11.3 days. Detection time for NTM was 19.2 days. Among 96 isolates 95 (98.96 %) were M. tuberculosis and remaining 1 (1.04 %) was photochromogen Non-tuberculous Mycobacteria (NTM). Out of 95 M. tuberculosis 51 (53.84 %) were resistant to at least one drug, 38 (40.00 %) to INH, 31 (32.63%) to RMP, 13(13.68 %) to SM, 11 (11.58 %) to EMB and 10 (10.53 %) to PZA and multi-drug resistant tuberculosis (MDR-TB) was 21 (22.11 %). Resistance to one drug was 21 (22.11%), two drugs 15 (15.79 %), to three drugs 10 (10.53 %) and resistant to four or more drugs 5(5.26 %) cases.

Bangladesh J Med Microbiol 2010; 03 (02): 13-17

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Published

2010-06-25

How to Cite

Wadud, A. A., Rahman, A. M., Miah, M. R. A., & Saleh, A. A. (2010). Drug Resistance Pattern of <i>Mycobacterium tuberculosis</i> Isolated from Patients Attending a Referral Hospital. Bangladesh Journal of Medical Microbiology, 3(2), 13–17. https://doi.org/10.3329/bjmm.v3i2.5321

Issue

Vol. 3 No. 2 (2009)

Section

Original Articles