Molecular epidemiology and antimicrobial susceptibility of carbapenemase-producing extraintestinal Escherichia coli in a tertiary care hospital of Dhaka, Bangladesh

Authors

  • Fatima Afroz Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Shaheda Anwar Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Rokshana Akhtar Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Ahmed Abu Saleh Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/bjmm.v14i1.57758

Keywords:

Escherichia coli, carbapenemase, NDM, OXA-48, molecular epidemiology, antimicrobial resistance, Bangladesh

Abstract

The emergence of carbapenemase producing Escherichia coli, the first hospital and community-acquired opportunistic pathogen now become a great public health concern. A total of 23 clinical isolates of carbapenemase producing E. coli from extraintestinal infections in a tertiary care hospital of Bangladesh were studied. Highest percentage of carbapenemase producing E. coli isolates were from urine samples (52.2%) followed by 21.7% from each of wound swab and pus and 4.1 % from blood samples. Among the E. coli isolates 69.6% were from indoor patients and 30.4% were from outdoor patients. All the isolates (100%) were positive for NDM of which 13% were NDM and OXA-48 co-producers by conventional PCR. Carbapenemase producing E. coli isolates were resistant to most of the antibiotic tested except for nitrofurantoin, colistin, polymyxin B and tigecycline with a sensitivity of 66.7%, 82.6%, 95.7% and 100% respectively.

Bangladesh J Med Microbiol 2020; 14 (1): 3-6

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Published

2020-01-31

How to Cite

Afroz, F. ., Anwar, S. ., Akhtar, R. ., & Saleh, A. A. . (2020). Molecular epidemiology and antimicrobial susceptibility of carbapenemase-producing extraintestinal Escherichia coli in a tertiary care hospital of Dhaka, Bangladesh. Bangladesh Journal of Medical Microbiology, 14(1), 3–6. https://doi.org/10.3329/bjmm.v14i1.57758

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Section

Original Articles