Antecedent Infections and Hospital Outcomes in Demyelinating and Axonal type of Guillain-Barre Syndrome among adult Patients

Authors

  • Md Zakirul Islam Assistant Professor, Department of Medicine, Kurmitola General Hospital, Dhaka, Bangladesh https://orcid.org/0009-0002-9772-7152
  • Anjuman Ara Assistant Professor, Department of Gynaecology & Obstetrics, TMSS Medical College, Bogura, Bangladesh
  • Syeda Marufa Hasan Associate Professor (C.C.), Department of Biochemistry, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
  • Md Abdullah Yusuf Associate professor, Department of Microbiology, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh https://orcid.org/0000-0002-8551-7185
  • Rezaul Karim Senior Consultant (Medicine), Department of Medicine, General Hospital Nilpharmary, Bangladesh
  • Md Azharul Hoque Former Head & Professor of Neurology, Department of Neurology, National Institute of Neurosciences and Hospital, Dhaka, Bangladesh
  • Quazi Deen Mohammad Director & Professor of Neurology, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh https://orcid.org/0000-0001-6009-0536

DOI:

https://doi.org/10.3329/bjmm.v16i1.65864

Keywords:

Guillain Barre syndrome, acute inflammatory demyelinating polyneuroradiculopathy, Acute Motor Axonal Polyneuroradiculopathy, hospital-outcomes

Abstract

Background: Many differences are observed with respect to hospital outcome among demyelinating and axonal type of Guillain-Barre Syndrome.

Objective: Aims of this study was to compare the hospital outcome at discharge among demyelinating and axonal type of Guillain-Barre syndrome.

Methodology: This prospective observational study was conducted from Oct, 2017 to September, 2018 at the National Institute of Neurosciences and Hospital, Dhaka, Bangladesh. All demyelinating and axonal variant of GBS, presented within 2 weeks were included in this study. The clinical parameters were taken for baseline analysis. Outcomes were measured at discharge by MRC score, length of hospital and ICU stay, recovery and death.

Results: Out of 108 GBS cases 55 (50.9%) demyelinating & 53 (49.1%) were axonal subtype. Mean age; 40.20 ± 16.26 vs. 32.43 ± 14.93 years in demyelinating vs. axonal cases (p=0.011). Symptom onset and nadir of weakness are quicker in axonal than demyelinating cases (8.47±4.97 vs. 12.36±7.94) (p=0.017) and (6.7 ± 4.5 vs. 8.36 ± 4.59) (p=0.022)] days. Baseline MRC score were (18.04±9.85 vs 12.94±9.91) (p=0.009) demyelinating vs. axonal cases. At discharge, Mean MRC score, length of hospital stay, length of ICU stay were, (22.15±9.38 vs 17.39±9.46; p=0.013); (15.13±17.60 vs 23.58±23.55) days (p=0.038)} and (28.69±23.28 vs 37.0±20.01) days respectively.

Conclusion: Hospital outcome of GBS patients is favorable to demyelinating subtype in respect of MRC score, length of hospital stay, length of ICU stay and also death and survivability.

Bangladesh Journal of Medical Microbiology, January 2022;16(1):19-24

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Published

2023-07-21

How to Cite

Islam, M. Z., Ara, A. . ., Hasan, S. M. . ., Yusuf, M. A. . ., Karim, R. . ., Hoque, M. A. . ., & Mohammad, Q. D. . . (2023). Antecedent Infections and Hospital Outcomes in Demyelinating and Axonal type of Guillain-Barre Syndrome among adult Patients. Bangladesh Journal of Medical Microbiology, 16(1), 19–24. https://doi.org/10.3329/bjmm.v16i1.65864

Issue

Vol. 16 No. 1 (2022)

Section

Original Articles