Pharmacogenomics- The Promise of Personalized Medicine

Authors

  • M Fakruddin Scientific Officer, Industrial Microbiology Laboratory, Institute of Food Science and Technology (IFST), Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka
  • A Chowdhury Institute of Food Science and Technology (IFST), Bangladesh Council of Scientific and Industrial Research (BCSIR)

DOI:

https://doi.org/10.3329/bjms.v12i4.11041

Keywords:

Pharmacogenomics, Applications, ethics, challenges, prospects

Abstract

Introduction: Pharmacogenomics (PGx) is the study of the genetic basis of variability among individuals in response to drugs. It is the newest discipline of medicine and is becoming a very active area of research, with the pharmaceutical industry gaining experience applying it, integrating it into the drug development process, and also learning to better manage the expectations of the medical community.

Methodology: A comprehensive review of the literature on the principles, applications, challenges and prospects of pharmacogenomics was performed.

Results: Pharmacogenomics tailors therapies to the genetic makeup of an individual and can therefore offer treatments that are more efficacious and have fewer side effects. Despite these benefits, personalized medicine has not been embraced by large pharmaceutical companies. It is expected that the first wave of successful pharmacogenomics products will be used in acute treatments for which current therapies have and severe side effects. These products should also be good candidates for premium pricing. Personalized medicine (PM), based on the genetic makeup of a patient, may result in not only an improved therapeutic response but also a clinically important reduction in adverse drug reactions. The experience to date is mixed, with a few successes but many frustrations.

Conclusion: However, for pharmacogenomics to be truly embraced, the benefits of this technology must become more widely accepted in terms of economic, public, regulatory and ethical issues.

DOI: http://dx.doi.org/10.3329/bjms.v12i4.11041

Bangladesh Journal of Medical Science Vol. 12 No. 04 October 13 Page 346-356

Downloads

Download data is not yet available.
Abstract
238
PDF
121

Downloads

Additional Files

Published

2013-10-26

How to Cite

Fakruddin, M., & Chowdhury, A. (2013). Pharmacogenomics- The Promise of Personalized Medicine. Bangladesh Journal of Medical Science, 12(4), 346–356. https://doi.org/10.3329/bjms.v12i4.11041

Issue

Vol. 12 No. 4 (2013)

Section

Review Article

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.