Outcome of Tumor Lysis Syndrome with Hydration and Alkalinization in Children with Acute Lymphoblastic Leukemia

Authors

  • Armin Sultana Department of Pediatrics, BSMMU
  • Afiqul Islam Professor and Chairman, Department of Pediatric Hemato Oncology, BSMMU
  • Gulshan Akhtar Assistant Professor, Department of Paediatrics, Green Life Medical College and Hospital, Green Road, Dhaka
  • Md Abdur Rahman Medical Officer, BG Press, GOD, Tejgaon Dhaka

DOI:

https://doi.org/10.3329/bjms.v11i4.12598

Keywords:

Hydration, Alkalinization

Abstract

Objective: To observe the out come of tumor lysis syndrome (TLS) following treatment with hydration and alkalinization in children with acute lymphoblastic leukemia.

Methodology: This is an observational study which included 30 diagnosed ALL children who were at high risk of developing TLS in the Department of Pediatric Hematology & Oncology, BSMMU, from January 2010 to July 2010.

Result: The mean (±SD) age was found 10.2±2.9 years and maximum (46.7%) numbers were found between 11 to 15 years. Male female ratio was 2.3:1. High risk patients for developing TLS presented with huge organomegaly such as hepatomegaly, splenomegaly, and lymphadenopathy associated with fever, anemia, and bony tenderness. For diagnosis of Acute Lymphoblastic Leukemia (ALL) bone marrow study was done in all patients and immunophenotyping in 40.0% patients. Hydration, Alkalinization, Tab Allopurinol and Oral Aluminum hydroxide were used in all study patients while treatment. WBC and serum uric acid were found higher in all patients during baseline investigation. After hydration and Alkalinization serum potassium, serum phosphate, serum calcium and serum creatinine level were normal within 72 hours and serum uric acid within day five. Mortality was found 6.7% and the cause of mortality was septicemia.

DOI: http://dx.doi.org/10.3329/bjms.v11i4.12598

Bangladesh Journal of Medical Science Vol. 11 No. 04 Oct12

 

Downloads

Download data is not yet available.
Abstract
180
PDF
104

Downloads

Published

2012-11-13

How to Cite

Sultana, A., Islam, A., Akhtar, G., & Rahman, M. A. (2012). Outcome of Tumor Lysis Syndrome with Hydration and Alkalinization in Children with Acute Lymphoblastic Leukemia. Bangladesh Journal of Medical Science, 11(4), 284–291. https://doi.org/10.3329/bjms.v11i4.12598

Issue

Vol. 11 No. 4 (2012)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.