Outcome of Tumor Lysis Syndrome with Hydration and Alkalinization in Children with Acute Lymphoblastic Leukemia

Authors

  • Armin Sultana Department of Pediatrics, BSMMU
  • Afiqul Islam Professor and Chairman, Department of Pediatric Hemato Oncology, BSMMU
  • Gulshan Akhtar Assistant Professor, Department of Paediatrics, Green Life Medical College and Hospital, Green Road, Dhaka
  • Md Abdur Rahman Medical Officer, BG Press, GOD, Tejgaon Dhaka

DOI:

https://doi.org/10.3329/bjms.v11i4.12598

Keywords:

Hydration, Alkalinization

Abstract

Objective: To observe the out come of tumor lysis syndrome (TLS) following treatment with hydration and alkalinization in children with acute lymphoblastic leukemia.

Methodology: This is an observational study which included 30 diagnosed ALL children who were at high risk of developing TLS in the Department of Pediatric Hematology & Oncology, BSMMU, from January 2010 to July 2010.

Result: The mean (±SD) age was found 10.2±2.9 years and maximum (46.7%) numbers were found between 11 to 15 years. Male female ratio was 2.3:1. High risk patients for developing TLS presented with huge organomegaly such as hepatomegaly, splenomegaly, and lymphadenopathy associated with fever, anemia, and bony tenderness. For diagnosis of Acute Lymphoblastic Leukemia (ALL) bone marrow study was done in all patients and immunophenotyping in 40.0% patients. Hydration, Alkalinization, Tab Allopurinol and Oral Aluminum hydroxide were used in all study patients while treatment. WBC and serum uric acid were found higher in all patients during baseline investigation. After hydration and Alkalinization serum potassium, serum phosphate, serum calcium and serum creatinine level were normal within 72 hours and serum uric acid within day five. Mortality was found 6.7% and the cause of mortality was septicemia.

DOI: http://dx.doi.org/10.3329/bjms.v11i4.12598

Bangladesh Journal of Medical Science Vol. 11 No. 04 Oct12

 

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Published

2012-11-13

How to Cite

Sultana, A., Islam, A., Akhtar, G., & Rahman, M. A. (2012). Outcome of Tumor Lysis Syndrome with Hydration and Alkalinization in Children with Acute Lymphoblastic Leukemia. Bangladesh Journal of Medical Science, 11(4), 284–291. https://doi.org/10.3329/bjms.v11i4.12598

Issue

Vol. 11 No. 4 (2012)

Section

Original Articles

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