Scedosporium apiospermum fungaemia: the ramification of broad-spectrum antimicrobial treatments

Authors

  • Chuan Hun Ding Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur
  • Najihan Abdul Samat Muttaqillah Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur
  • Md. Mostafizur Rahman Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur
  • Nor Zanariah Zainol Abidin Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur
  • Suvra Biswas Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur
  • Mohd Nizam Tzar Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur

DOI:

https://doi.org/10.3329/bjms.v13i3.19154

Keywords:

Amphotericin B, fungaemia, Pseudallescheria boydii, Scedosporium apiospermum, broad spectrum

Abstract

Scedosporium apiospermum is a cosmopolitan mycotic agent with unique characteristics. This is a case of a 65-year-old immunocompetent patient who presented with shortness of breath and fever. Consolidation was observed in both lung fields on chest X-ray. A diagnosis of aspiration pneumonia was made. Extended-spectrum ?-lactamase (ESBL)-producing Klebsiella pneumoniae was identified from his tracheal aspirate and imipenem was administered. Initial blood cultures were negative but after 10 days on imipenem, Candida glabrata was isolated. Amphotericin B was added to the treatment regimen, but after a week on this antifungal, Scedosporium apiospermum was cultured from the blood. The patient succumbed to illness before a change in the antifungal regimen. The case highlights the unwelcome consequence of using a broad spectrum antibiotic and later a broad spectrum antifungal agent.

DOI: http://dx.doi.org/10.3329/bjms.v13i3.19154

Bangladesh Journal of Medical Science Vol.13(3) 2014 p.326-328

Note: updated with minor changes on 20th June 2014. Last author added.

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Author Biographies

Chuan Hun Ding, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur

Department of Medical Microbiology & Immunology

Najihan Abdul Samat Muttaqillah, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur

Department of Medical Microbiology & Immunology

Md. Mostafizur Rahman, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur

Department of Medical Microbiology & Immunology

Nor Zanariah Zainol Abidin, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur

Department of Medical Microbiology & Immunology

Suvra Biswas, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur

Department of Medical Microbiology & Immunology

Mohd Nizam Tzar, Universiti Kebangsaan Malaysia Medical Centre, Cheras 56000, Kuala Lumpur

Department of Medical Microbiology & Immunology

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Published

2014-06-15

How to Cite

Ding, C. H., Muttaqillah, N. A. S., Rahman, M. M., Abidin, N. Z. Z., Biswas, S., & Tzar, M. N. (2014). Scedosporium apiospermum fungaemia: the ramification of broad-spectrum antimicrobial treatments. Bangladesh Journal of Medical Science, 13(3), 326–328. https://doi.org/10.3329/bjms.v13i3.19154

Issue

Vol. 13 No. 3 (2014)

Section

Case Reports

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