High-sensitivity C-reactive protein in Sri Lankan males with coronary artery disease

Authors

  • Chandima Madhu Wickramatilake Lecturer, Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle
  • Mohamad Rifdy Mohideen Professor in Medicine, IMU Clinical School, International Medical University, 6 Jalan Indah, Taman Sri Kenangan 8300, Batu Pahat Johor
  • Chitra Pathirana Senior Professor, Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle

DOI:

https://doi.org/10.3329/bjms.v15i1.19736

Keywords:

coronary artery disease, dyslipidaemia, high-sensitivity, C-reactive protein

Abstract

Objectives: Evidence suggests that inflammation and dyslipideamia play a key role in the pathogenesis of coronary artery disease (CAD). High sensitivity C-reactive protein (hs- CRP) is a sensitive marker of inflammation. We attempted to evaluate the contribution of dyslipidaemia and inflammation in CAD.

Materials and methods: Three hundred and nine males (103 with myocardial infarction - MI, 103 with established CAD, 103 healthy controls) were studied. The serum hs-CRP, lipids and plasma glucose were determined.

Results: Baseline mean hs-CRP levels in patients with established CAD and MI were significantly higher compared to controls (3.4 ± 1.62 VS. 1.70 ± 0.60 mg/L, p = 0.001) (3.7 ± 0.65 VS. 1.70 ± 0.60 mg/L, p = 0.001). A significant negative correlation observed between hs-CRP and HDL-Ch (r = -0.359, p = 0.001).

Conclusion: Inflammation (which was reflected by elevated hs-CRP) and dyslipidamia were associated with coronary artery disease.

Bangladesh Journal of Medical Science Vol.15(1) 2016 p.44-50

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Published

2016-04-11

How to Cite

Wickramatilake, C. M., Mohideen, M. R., & Pathirana, C. (2016). High-sensitivity C-reactive protein in Sri Lankan males with coronary artery disease. Bangladesh Journal of Medical Science, 15(1), 44–50. https://doi.org/10.3329/bjms.v15i1.19736

Issue

Vol. 15 No. 1 (2016)

Section

Original Articles

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