Serum bone markers in pregnant women at Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital

Authors

  • Pasipanodya Ian Machingura College of Health Sciences, University of Zimbabwe
  • Kudakwashe Muringai College of Health Sciences, University of Zimbabwe
  • Vasco Chikwasha College of Health Sciences, University of Zimbabwe

DOI:

https://doi.org/10.3329/bjms.v14i4.20080

Keywords:

serum calcium, serum inorganic phosphate, serum alkaline phosphate, pregnancy

Abstract

Background: Pregnancy induces a number of physiological changes in the body including changes in bone profile. As the gestational period progresses and the foetus grows, its demand for mineral micronutrients increases inducing changes in the maternal body. Serum bone profile varies according to trimester as gestational period progresses. The study on which this article is based sought to determine changes in bone profile with trimester in pregnant women attending antenatal clinic at Parirenyatwa Group of Hospitals (PGH) and Chitungwiza Central Hospital, Zimbabwe. Method: An analytical cross sectional study was conducted on pregnant women attending antenatal clinics at Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital. A questionnaire was administered and blood samples were collected for analysis of albumin, corrected calcium, phosphate and alkaline phosphatase. Results: A total of 171 pregnant women were recruited into the study. The albumin level showed a significant fall from trimester 1 to 2 (P<0.05) and an insignificant rise from trimester 2 to 3 (P>0.05). Conclusion: This study confirms the previously reported constant serum inorganic phosphate level throughout the gestational period and an increase in alkaline phosphatase with gestational age. Corrected calcium level had a statistically significant increase from the second to the third trimester (P<0.05). This study provided exploratory data on serum bone markers. Further research on more specific bone markers such as DEXA and bone specific alkaline phosphatase is required. A continual check of at risk women is needed to be able to advice on dietary supplementation to prevent premature osteoporosis.

Bangladesh Journal of Medical Science Vol.14(4) 2015 p.363-366

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Author Biographies

Pasipanodya Ian Machingura, College of Health Sciences, University of Zimbabwe

Lecturer, Department of Medical Laboratory Sciences

Kudakwashe Muringai, College of Health Sciences, University of Zimbabwe

Department of Medical Laboratory Sciences

Vasco Chikwasha, College of Health Sciences, University of Zimbabwe

Department of Community Medicine

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Published

2015-12-11

How to Cite

Machingura, P. I., Muringai, K., & Chikwasha, V. (2015). Serum bone markers in pregnant women at Parirenyatwa Group of Hospitals and Chitungwiza Central Hospital. Bangladesh Journal of Medical Science, 14(4), 363–366. https://doi.org/10.3329/bjms.v14i4.20080

Issue

Vol. 14 No. 4 (2015)

Section

Original Articles

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