The Effect of L-Carnitine and Proinflammatory Cytokines in the Development of Nonalcoholic Steatohepatitis

Authors

  • Tetyana Dmitrivna Zvyagintseva Department of Gastroenterology, Kharkov Medical Academy of Postgraduate Education, Kharkov
  • Svetlana Vladimirovna Glushchenko Doctor, Department of Gastroenterology, Kharkov Medical Academy of Postgraduate Education, Kharkov

DOI:

https://doi.org/10.3329/bjms.v15i1.20660

Keywords:

nonalcoholic steatohepatitis, L-carnitine, TNF-?, IL-6

Abstract

Objective: research is to study the role of L-carnitine, tumor necrosis factor ? (TNF-?), and interleucine-6 (IL-6) in the development of NASH.

Materials and Methods: examined 65 patients with NASH. Blood serum L-carnitine, TNF-? and IL-6 level was estimated using the enzyme-linked immunoassay method.

Results: patients with NASH had a decreased blood serum level of L-carnitine. L-carnitine level was found to be in strong inverse correlation dependence on cellular damage markers, L-carnitine levels affect the performance TNF-? and IL-6.

Conclusion: L-carnitine contributes to lipotoxic stress development and development of systemic liver inflammation.

Bangladesh Journal of Medical Science Vol.15(1) 2016 p.62-65

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Published

2016-04-11

How to Cite

Zvyagintseva, T. D., & Glushchenko, S. V. (2016). The Effect of L-Carnitine and Proinflammatory Cytokines in the Development of Nonalcoholic Steatohepatitis. Bangladesh Journal of Medical Science, 15(1), 62–65. https://doi.org/10.3329/bjms.v15i1.20660

Issue

Vol. 15 No. 1 (2016)

Section

Original Articles

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