Aldosterone levels and the -344t/C aldosterone synthase in individuals with a family history of hypertension

Authors

  • Ika Setyawati Department of Biochemistry, Faculty of Medicine, Muhammadiyah University, Yogyakarta
  • Sunarti -
  • Pramudji Hastuti Department of Biochemistry, Faculty of Medicine, Gadjah Mada Univertisy, Yogyakarta

DOI:

https://doi.org/10.3329/bjms.v15i3.25791

Keywords:

Aldosterone, Aldosterone synthase, Hypertension, Polymorphism

Abstract

Background: Genetic factors play an important role in the determination of hypertensive disease in a family. The -344T/C the aldosterone synthase gene has been reported in various populations closely related to hypertension. The aim of this study was to determine the presence of the -344T/C polymorphism of the aldosterone synthase gene and the levels of plasma aldosterone in individuals with and without a family history of hypertension.

Methods: This study was a case control design, with healthy individuals with a family history of hypertension as cases (n-42) and those without a family history of hypertension as controls (n=41). The subjects plasma aldosterone levels were analysed by enzyme-link immunosorbent assay (ELISA) and the gene polymorphism was analysed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The data were analysed by an independent sample T-test and Chi square test, and the significance level was set at P<0.05.

Result: The frequency of the TT + TC genotype was higher in cases, and this increase was significant different compared to the controls (P<0.046). The frequency of the TT + TC genotype was 2.56 higher in cases than controls. The frequency of the C allele in cases was also significantly different compared to the controls (P = 0.039) and 2.29 more frequent in cases than the controls (P = 0.039). The plasma aldosterone level was 42.35 pg/dL in cases and 34.9 pg/dL in controls (P = 0.616). Plasma aldosterone level in cases with the CC, TC and TT genotypes were 48.29, 40.8 and 35.2 pg/dL, respectively (P = 0.774). Our study concludes that individuals with a family history of hypertension are at a higher risk of developing hypertension. Follow-up studies are required to determine the incidence of hypertension in a person with a family history of hypertension and who is a carrier of genetic risk factors.

Bangladesh Journal of Medical Science Vol.15(3) 2016 p.435-440

Downloads

Download data is not yet available.
Abstract
1131
PDF
976

Downloads

Published

2016-11-03

How to Cite

Setyawati, I., -, S., & Hastuti, P. (2016). Aldosterone levels and the -344t/C aldosterone synthase in individuals with a family history of hypertension. Bangladesh Journal of Medical Science, 15(3), 435–440. https://doi.org/10.3329/bjms.v15i3.25791

Issue

Vol. 15 No. 3 (2016)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.