Apoptotic Molecules In Chronic Leukemia

Authors

  • Faris Q Alenzi College of Appl.Med.Sci, Prince Sattam bin Abdulaziz University, Al-Kharj
  • Amani A Ballow MD Labs, AlHabib Hospital
  • Meaad Q Alanazi Department of Nursing, KAMC, Riyadh
  • Fahad G Alanazi MOH Hospitals, Riyadh
  • Omar Bagader MOH Hospitals, Riyadh
  • Abdulrahman Q Alanazi MOH Hospitals, Riyadh

DOI:

https://doi.org/10.3329/bjms.v15i4.30724

Abstract

Background: Chronic myeloid leukemia (CML) is characterized by the spread of malignant cells that exhibit resistance to caspase-mediated cell death (apoptosis) and this mechanism is proposed to play an important role in myeloid cell growth. However, the extent to which caspase-mediated cell death plays a crucial role in the regulation of myelopoiesis remains controversial.

Objectives & Proceedure: The objectives of this study were to examine whether or not caspase-mediated cell death-related proteins take part in the development of CML and to also to detect the relationship between Fas, p53 and caspase-mediated cell death protease activating factor (Apaf-1) in 5 patients with CML using the real-time quantitative polymerase chain reaction. We demonstratedthatp53 and Apaf-1 messenger ribonucleic acid (mRNA) expression was moderately elevated (up to 5 fold, p<0.05) in 4 out of 5 CML patients. One patient with a p53 point mutation, exhibited a far greater elevation of p53 mRNA expression throughout their blast crisis, but in contrast, displayed a significant reduction in levels of Apaf-1 mRNA and Fas mRNA.

Conclusion: Our results show in-vivo linkages between Fas, p53 and Apaf-1 transcription parameters suggesting that the key genes involved in the caspase-mediated cell death might contribute to CML disease development.

Bangladesh Journal of Medical Science Vol.15(4) 2016 p.651-654

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Author Biography

Faris Q Alenzi, College of Appl.Med.Sci, Prince Sattam bin Abdulaziz University, Al-Kharj



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Published

2016-12-18

How to Cite

Alenzi, F. Q., Ballow, A. A., Alanazi, M. Q., Alanazi, F. G., Bagader, O., & Alanazi, A. Q. (2016). Apoptotic Molecules In Chronic Leukemia. Bangladesh Journal of Medical Science, 15(4), 651–654. https://doi.org/10.3329/bjms.v15i4.30724

Issue

Vol. 15 No. 4 (2016)

Section

Case Reports

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