Raised ?2-Microglobulin as a Surrogate Marker in Non-Secretory Multiple Myeloma

Authors

  • Bimal K Agrawal Department of Medicine, M M Institute Of Medical Sciences &Research, M M University, MULLANA-133207(Ambala)
  • Anshul Sehgal Department of Medicine, M M Institute Of Medical Sciences &Research, M M University, MULLANA-133207(Ambala)
  • Vikas Deswal Department of Medicine, M M Institute Of Medical Sciences &Research, M M University, MULLANA-133207(Ambala)
  • Prem Singh Department of Pathology, M M I M S R M M University, Mullana-133207
  • Usha Agrawal National Institute Of Pathology, Indian Council of Medical Research, New Delhi-110029

DOI:

https://doi.org/10.3329/bjms.v16i1.31146

Keywords:

nonsecretory myeloma, neurocognitive impairment, ?2 microglobulin

Abstract

Multiple myeloma is a neoplasm of plasma cells in the bone marrow. It is characterised by lytic lesions in the bones, marrow plasmacytosis and presence of M protein in serum and/or urine. Serum ?2 microglobulin is also raised and can be used for classification and prognostication of the disease. In the absence of M protein, the disease is known as non-secretory myeloma. It is proposed that raised ?2 microglobulin can be used for diagnosis and therapeutic guidance in the absence of M protein. A rare case of nonsecretory myeloma with neurocognitive impairment along with review of literature is being presented. The patient had multiple lytic lesions in bones with marked increase in plasma cells in bone marrow. M protein was not detectable in serum or urine but serum ?2 microglobulin was much elevated.

Bangladesh Journal of Medical Science Vol.16(1) 2017 p.142-145

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Author Biography

Bimal K Agrawal, Department of Medicine, M M Institute Of Medical Sciences &Research, M M University, MULLANA-133207(Ambala)



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Published

2017-01-16

How to Cite

Agrawal, B. K., Sehgal, A., Deswal, V., Singh, P., & Agrawal, U. (2017). Raised ?2-Microglobulin as a Surrogate Marker in Non-Secretory Multiple Myeloma. Bangladesh Journal of Medical Science, 16(1), 142–145. https://doi.org/10.3329/bjms.v16i1.31146

Issue

Vol. 16 No. 1 (2017)

Section

Case Reports

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