Helicobacter Pylori is associated with decrease serum level of the thyroid hormonal in healthy elderly population

Authors

  • Sri Suwarni Student at Doctoral Program of Medical Sciences, Faculty of Medicine Sebelas Maret University Indonesia
  • Cilmiaty Risya Doctoral Program of Medical Sciences, Faculty of Medicine Sebelas Maret University Indonesia & Dental and Oral Departement of Moewardi Hospital Indonesia
  • Dono Indarto Biomedic Laboratory, Faculty of Medicine Sebelas Maret University Indonesia
  • Suradi Pulmonology Departement of Moewardi Hospital Indonesia & Doctoral Program of Medical Sciences, Faculty of Medicine Sebelas Maret University Indonesia

DOI:

https://doi.org/10.3329/bjms.v16i4.33604

Keywords:

Heliccobacter pylori, serum T3 level, serum TSH level, healthy elderly population

Abstract

Background: Helicobacter pylori infection is the most prevalence infectious disease as it affects more than half of the world population and causes chronic cellular inflammatory response in the gastric mucosa. Helicobacter pylori infection has been epidemiologically proven to be linked to extra-digestive conditions and disease. It has been speculated that H.pylori infection may be responsible for various endocrine disorders. The thyroid may be one of the targets of Helicobacter pylori chronic inflammation. Here we sought too investigate whether H.pylori infections were associated with decrease level of the thyroid hormonal.

Methods: This study involved elderly aged 50-90 years who had visited a health promotion center for elderly. A total 101 euthyroid subjects were been enrolled in this cross-sectional study. Diagnosed of Helicobacter.pylori infections by ELISA of Ig G antibodies of Helicobacter pylori. We examine serum T3 level and serum TSH level by ELEXIS. For statistical method we use Pearson bivariat analysis to determine the association of two variable,and linier regression to determine which variable is more influented by Helicobacter pylori.

Results: Fourty-two (41,6 %) subjects had been diagnosed with H.pylori infections. Pearson bivariat analysis showed that Helicobacter pylori infection was significantly associated with decreased serum T3 level ( correlations coefficient r = -0,66 ,p< 0,001 ). The prevalence of Helicobacter pylori infection showed a increasing trend as serum TSH level decreased (correlations coefficient r = -0,53, p < 0,001). Linier regression analysis showed thatHelicobacter pylori infection was significantly associated with the risk of decreased thyroid hormonal fuction ( B = -0,272. R2 = 0,676. P < 0.001 ).

Conclusion: Our results suggested that H.pylori infections were significantly associated with the decreased serum level of T3 and TSH serum level in the healthy elderly population, whose thyroid functions were in the reference range.

Bangladesh Journal of Medical Science Vol.16(4) 2017 p.515-520

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Author Biography

Sri Suwarni, Student at Doctoral Program of Medical Sciences, Faculty of Medicine Sebelas Maret University Indonesia



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Published

2017-08-19

How to Cite

Suwarni, S., Risya, C., Indarto, D., & Pulmonology, S. (2017). Helicobacter Pylori is associated with decrease serum level of the thyroid hormonal in healthy elderly population. Bangladesh Journal of Medical Science, 16(4), 515–520. https://doi.org/10.3329/bjms.v16i4.33604

Issue

Vol. 16 No. 4 (2017)

Section

Original Articles

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