Serum level of il-6 in patients of type-ii diabetes mellitus with and without retinopathy: a comparative study

Authors

  • Nadeem Afzal Department of Immunology, University of Health Sciences, Lahore
  • Rasheed Anjum Department of Medical Education, University of Health Sciences Lahore
  • Ahmed Nadeem Department of Immunology, University of Health Sciences, Lahore
  • Khursheed Javed Department of Immunology, University of Health Sciences, Lahore
  • Faheem Shahzad Department of Immunology, University of Health Sciences, Lahore
  • Muhammad Kashif Department of Immunology, University of Health Sciences, Lahore
  • Abu Zafar Amin Hayat Memorial Diabetic Centre, Lahore
  • Shakeela Zaman Children Hospital & Institute of Child Health, Lahore
  • AH Nagi Department of Pathology, University of Health Sciences, Lahore

DOI:

https://doi.org/10.3329/bjms.v16i4.33606

Keywords:

Cytokine, diabetes mellitus, HbA1c, ELISA, IL-6, inflammation, retinopathy, hyperglycemia

Abstract

Aim: Pakistan has 6.9 million people with diabetes mellitus (DM) that will be doubled by 2025. A study was designed to determine serum levels of IL-6 in type 2 diabetes mellitus (T2DM) patients.

Methods: It was a cross-sectional case-control study of 212 subjects. Group-I included 30 subjects without DM, Group-II had 30 T2DM without retinopathy and Group-III had 152 T2DM with retinopathy. IL-6 was determined by ELISA technique. Data was analysed using SPSS 17.0.

Results: More females were in Group-II (83%) and Group-III (66%) compared to Group-I (30%). Higher age was in Group-II (49yrs) and Group-III (50yrs) compared to Group-I (34yrs). Mean duration of disease (in years) was more in Group-III (10.51) than Group-II (7.76). Highest mean level of IL-6 was in Group-II, followed by Group-I and Group-III. On comparison, gender, age, duration of disease and the level of IL-6, there was a significant difference while there was no significant difference between percentages of HbA1c. The logistic regression model suggested low levels of IL-6 in patients of diabetic retinopathy was an independent predictor of retinopathy in patients with T2DM.

Conclusion: Serum level of IL-6 was low in patients of diabetic retinopathopathy as compared to patients with T2DM without retinopathy.

Bangladesh Journal of Medical Science Vol.16(4) 2017 p.525-529

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Author Biography

Nadeem Afzal, Department of Immunology, University of Health Sciences, Lahore



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Published

2017-08-19

How to Cite

Afzal, N., Anjum, R., Nadeem, A., Javed, K., Shahzad, F., Kashif, M., Zafar, A., Zaman, S., & Nagi, A. (2017). Serum level of il-6 in patients of type-ii diabetes mellitus with and without retinopathy: a comparative study. Bangladesh Journal of Medical Science, 16(4), 525–529. https://doi.org/10.3329/bjms.v16i4.33606

Issue

Vol. 16 No. 4 (2017)

Section

Original Articles

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