Renal function in Thalassemia major patients who treated by Desferal

Authors

  • Mandana Zafari Health Reproductive Research Center, Sari Branch, Islamic Azad University, Sari
  • Azar Aghamohammady Health Reproductive Research Center, Sari Branch, Islamic Azad University, Sari
  • Masoomeh Mosavy Thelassemia Research Centre, Mazandaran University of Medical Science

DOI:

https://doi.org/10.3329/bjms.v17i1.35281

Keywords:

transfusion dependent Thalassemia major, Desferal, renal function

Abstract

Background and purpose: β-thalassemia is the most common inherited hemoglobinopathy in all over the world. Iron over load will be appearing in kidney following blood transfusion. Desferal is one of iron chelator that can be ended renal complication. The aim of this study is evaluation the renal function in β- Thalassemia patients who were treated by Desferal.

Materials and methods: in this descriptive and analytic study 40 thalassemia patients who were treated by Desferal and 40 non Thalassemia subjects enrolled in this study randomly. For evaluation the renal function in these groups, we measured the Cr, BUN, K, Na, Uric acid, β-2 globin, Ca, Mg, P and Urea of blood and Na, K, Cr, protein and volume of urine 24 hours. We compared these variables between two groups. Also descriptive and analytic analyses were used, the significant level in this study was p≤0.05.

Results: comparing the renal function between two groups show that; the level of Na, Ca, K and β-2 Globin in serum and Cr, protein and urine volume in 24 hours had significant difference.

Conclusion: renal dysfunction such as; glomerular and tubular dysfunction and reduced filtration capacity are common in β-thalassemia patients.

Bangladesh Journal of Medical Science Vol.17(1) 2018 p.58-61

Downloads

Download data is not yet available.
Abstract
16
PDF
25

Downloads

Published

2018-01-11

How to Cite

Zafari, M., Aghamohammady, A., & Mosavy, M. (2018). Renal function in Thalassemia major patients who treated by Desferal. Bangladesh Journal of Medical Science, 17(1), 58–61. https://doi.org/10.3329/bjms.v17i1.35281

Issue

Vol. 17 No. 1 (2018)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.