Comperative phyto toxicological and anti inflammatory effects of leaves extracts of holoptelea integrifolia

Authors

  • Hina Yasin Baqai institute of Pharmaceutical Sciences, Baqai Medical University & Dow College of Pharmacy, Dow University of Health Sciences
  • Shaukat Khalid Baqai institute of Pharmaceutical Sciences, Baqai Medical University
  • Hina Abrar Department of Pharmacology, Baqai institute of Pharmaceutical Sciences, Baqai Medical University
  • Ghazala H Rizwani Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi
  • Rehana Perveen Baqai institute of Pharmaceutical Sciences, Baqai Medical University
  • Kaneez Fatima Baqai institute of Pharmaceutical Sciences, Baqai Medical University

DOI:

https://doi.org/10.3329/bjms.v17i2.35873

Keywords:

Holoptelea integrifolia, phytotoxicity, insecticidal activity, enzyme inhibition activity, Anti-inflammatory activity, Brine Shrimp Bioassay

Abstract

Objective: Plants play valuable role in the new drug discovery and significantly used to treat different diseases. Nowadays scientists are investigating the therapeutically active phytochemical constituents that are safe and producing lesser side effect in comparative to other standard drugs.

Methods: The plant Holoptelea integrifolia is medicinally important and this study was carried out to evaluate the anti inflammatory activity of aqueous extract of the leaves of Holoptelea integrifolia in male albino rats wistar stain treated with acetic acid to induced paw edema.

Results: Result indicated the significant anti-inflammatory activity while compared with standard drug (diclofenac sodium).Brine shrimp bioassay (cytotoxicity), phytotoxicity, insecticidal and enzyme inhibition activity was performed in different extracts of the leaves of H. integrifolia. Results of brime shrimp bioassay indicating positive lethality at high dose in BuOH and H2O only. While the results of phytotoxicity in all crude extracts displayed mild phytotoxicity(46.3 µg/ml) in high concentrations (1000 µg/ml) except H2O extract showed no phytotoxicity. Result of insecticidal activity revealed that BuOH extract were found more effective against Rhyzoperthadominica, the EtOH extract expressed major while EtOAC extract showed mild activity against Callosobruchusanalis. Aqueous extract possessed no insecticidal activity.

Conclusion: Results of Urease inhibition activity suggested that EtOAC and BuOH extracts of this plant expressed no activity while EtOH and H2O possessed mild inhibiting activity.

Bangladesh Journal of Medical Science Vol.17(2) 2018 p.212-217

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Author Biography

Hina Yasin, Baqai institute of Pharmaceutical Sciences, Baqai Medical University & Dow College of Pharmacy, Dow University of Health Sciences



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Published

2018-03-23

How to Cite

Yasin, H., Khalid, S., Abrar, H., Rizwani, G. H., Perveen, R., & Fatima, K. (2018). Comperative phyto toxicological and anti inflammatory effects of leaves extracts of holoptelea integrifolia. Bangladesh Journal of Medical Science, 17(2), 212–217. https://doi.org/10.3329/bjms.v17i2.35873

Issue

Vol. 17 No. 2 (2018)

Section

Original Articles

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