Extract Ethanol of Poguntano in Alloxan Induced Diabetic Rats

Authors

  • Sry Suryani Widjaja Biochemistry Department, Faculty of Medicine, USU, Medan
  • - Rusdiana University of Sumatera Utara Medical School, Biochemistry Department

DOI:

https://doi.org/10.3329/bjms.v17i2.35879

Keywords:

blood glucose, anti-diabetic, poguntano, diabetic rats, endothelin-1

Abstract

Back Ground: Diabetes mellitus is a group of metabolic disease with high blood glucose level above 150 mg/dL over a prolonged period. The elevated of blood glucose, free fatty acid and insulin resistance will cause the endothelial dysfunction, hemostasis disturbances that lead to micro and macrovascular complications. Poguntano (Picria fel-terrae Merr) from family Scrophulariaceae found in most part of Indonesia, has been used as traditional plant for treatment of diabetes.

Objective: The purpose of this study was to investigate the effect of extract ethanol of Poguntano in alloxan induced diabetic rats.

Method: Fifteen male Wistar rats with body weight of 150-200 gr were given intra peritoneal injection of 150 mg/kg Alloxan to induce diabetes. These were divided into three groups (control diabetic, group given insulin and group given Extract ethanol of Poguntano 200 mg/Kg body weight) and one control normal control. The duration of study was 4 weeks; blood glucose and Endothelin-1 were measured for all groups.

Results : Extract ethanol of Poguntano 200 mg showed significant results (p<0.001) in lowering blood glucose in Alloxan induced diabetic rats compared to control diabetic, but did not show superior to insulin group (p=0.892). Endothelin-1 showed statistical significant between group with normal rats and diabetic control rats. (p=0.009) but did not in the other groups. Levels of Endothelin-1 was higher in the diabetic control group with the median 1.95 (1,78- 3.1).

Conclusion: In our study we found that extract ethanol of Poguntano showed significant hypoglycemic activity and lowering the Endothelin-1 level in alloxan induced diabetic rats.

Bangladesh Journal of Medical Science Vol.17(2) 2018 p.251-254

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Author Biography

Sry Suryani Widjaja, Biochemistry Department, Faculty of Medicine, USU, Medan



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Published

2018-03-23

How to Cite

Widjaja, S. S., & Rusdiana, .-. (2018). Extract Ethanol of Poguntano in Alloxan Induced Diabetic Rats. Bangladesh Journal of Medical Science, 17(2), 251–254. https://doi.org/10.3329/bjms.v17i2.35879

Issue

Vol. 17 No. 2 (2018)

Section

Original Articles

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