Extract Ethanol of Poguntano in Alloxan Induced Diabetic Rats

Authors

  • Sry Suryani Widjaja Biochemistry Department, Faculty of Medicine, USU, Medan
  • - Rusdiana University of Sumatera Utara Medical School, Biochemistry Department

DOI:

https://doi.org/10.3329/bjms.v17i2.35879

Keywords:

blood glucose, anti-diabetic, poguntano, diabetic rats, endothelin-1

Abstract

Back Ground: Diabetes mellitus is a group of metabolic disease with high blood glucose level above 150 mg/dL over a prolonged period. The elevated of blood glucose, free fatty acid and insulin resistance will cause the endothelial dysfunction, hemostasis disturbances that lead to micro and macrovascular complications. Poguntano (Picria fel-terrae Merr) from family Scrophulariaceae found in most part of Indonesia, has been used as traditional plant for treatment of diabetes.

Objective: The purpose of this study was to investigate the effect of extract ethanol of Poguntano in alloxan induced diabetic rats.

Method: Fifteen male Wistar rats with body weight of 150-200 gr were given intra peritoneal injection of 150 mg/kg Alloxan to induce diabetes. These were divided into three groups (control diabetic, group given insulin and group given Extract ethanol of Poguntano 200 mg/Kg body weight) and one control normal control. The duration of study was 4 weeks; blood glucose and Endothelin-1 were measured for all groups.

Results : Extract ethanol of Poguntano 200 mg showed significant results (p<0.001) in lowering blood glucose in Alloxan induced diabetic rats compared to control diabetic, but did not show superior to insulin group (p=0.892). Endothelin-1 showed statistical significant between group with normal rats and diabetic control rats. (p=0.009) but did not in the other groups. Levels of Endothelin-1 was higher in the diabetic control group with the median 1.95 (1,78- 3.1).

Conclusion: In our study we found that extract ethanol of Poguntano showed significant hypoglycemic activity and lowering the Endothelin-1 level in alloxan induced diabetic rats.

Bangladesh Journal of Medical Science Vol.17(2) 2018 p.251-254

Downloads

Download data is not yet available.
Abstract
26
PDF
25

Author Biography

Sry Suryani Widjaja, Biochemistry Department, Faculty of Medicine, USU, Medan



Downloads

Published

2018-03-23

How to Cite

Widjaja, S. S., & Rusdiana, .-. (2018). Extract Ethanol of Poguntano in Alloxan Induced Diabetic Rats. Bangladesh Journal of Medical Science, 17(2), 251–254. https://doi.org/10.3329/bjms.v17i2.35879

Issue

Vol. 17 No. 2 (2018)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.