Study of Vitamin D levels in patients with Chronic Kidney Disease

Authors

  • SP Mittal Assistant Professor Medicinem, Department of Medicine. MM Medical College and Hospital Kumarhatti (Solan) - Himachal Pardesh (India)
  • Harendra Singh Sandhu Professor & Head of Department Medicine
  • Bant Singh Assistant Professor Medicine MM Medical College & Hospital Kumarhatti - Solan; Himachal Pardesh (India)

DOI:

https://doi.org/10.3329/bjms.v17i4.38332

Keywords:

Chronic Kidney Disease, Vitamin D, vitamin D Receptor, Hemodialysis

Abstract

Introduction: Apart from classical functions, vitamin D has autocrine function. Autocrine function of vitamin D has a potential impact on the morbidity and mortality in the Chronic Kidney Disease patients. This study is undertaken to observe probable modality, if present, between post Hemodialysis (HD) decrease in vitamin D levels and clinical deterioration in CKD patients.

Method & Material: 63 patients (32 males and 31 females) of Stage – 5 CKD were studied. There vitamin D was estimated before and after HD on first and subsequent maintenance HDs all patients with or without comorbidities.

Results: Pre HD total vitamin D levels were ‘deficient’ (58.73%) and ‘sufficient’ in 38.1%, almost equal in patients of both sexes despite intake of supplement containing Calcium and Calcitriol. Post HD vitamin D levels were detected to be markedly low, seems to be ‘washed out’ during HD, in 85.71% of patients (29 males and 27). Vitamin D ‘wash out’ effect was also observed in subsequent maintenance HDs. Females and elderly patients were more prone to vitamin D ‘wash out’. Conventional therapy with vitamin D supplements can replenish but could not prevent its post HD ‘wash out’.

Conclusion: It seems, in CKD the deleterious effects of post HD vitamin D deficiency are due to appreciable autocrine dysfunctions resulting in cardio vascular diseases (CVDs) and comorbidities especially diabetes mellitus add to worsening of CVDs, which are the main causes of high morbidity and mortality in these patients.

Bangladesh Journal of Medical Science Vol.17(4) 2018 p.652-660

Downloads

Download data is not yet available.
Abstract
2
PDF
1

Downloads

Published

2018-09-19

How to Cite

Mittal, S., Sandhu, H. S., & Singh, B. (2018). Study of Vitamin D levels in patients with Chronic Kidney Disease. Bangladesh Journal of Medical Science, 17(4), 652–660. https://doi.org/10.3329/bjms.v17i4.38332

Issue

Vol. 17 No. 4 (2018)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.