Assessment of oxidative damage and lipid profile levels in tobacco chewers with Type 2 diabetes mellitus

Authors

  • T Nagamma Selection Grade Lecturer, Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education, Manipal
  • Nirjala Laxmi Madhikarmi Associate Professor, Department of Biochemistry, Kantipur Dental College Teaching hospital & Research center, Kathmandu
  • Singh PP Visiting Professor, Era medical college, Lucknow

DOI:

https://doi.org/10.3329/bjms.v18i1.39554

Keywords:

Tobacco chewing; oxidative stress; antioxidants; hyperglycemia; Type 2 DM

Abstract

Objectives: To assess oxidative damage and lipid profile levels in Type 2 diabetes mellitus patients with or without tobacco chewing habit.

Methods: Total of 141 newly diagnosed Type 2 diabetes mellitus patients with tobacco chewing habit from past >18 years were included, 136 Type 2diabetes mellitus without any tobacco chewing habit, 140 normal healthy subjects without any tobacco chewing habit were included in the study. Blood sample was collected after 8-12 hours fasting from each subject to estimate glucose and cholesterol. The plasma was used for estimation of total antioxidant (TAA) activity, Vitamin C and thiobarbituric acid reacting substances (TBARS) by standard methods. Statistical analysis was done with SPSS version 16.

Results: The glucose, cholesterol and TBARS levels were found to be increased significantly (p<0.001) in diabetic patients with tobacco chewing habit, as well as TAA, Vitamin C levels decreased significantly (p<0.001) when compared with healthy individuals.

Conclusion: We observed increased oxidative stress and declined levels of antioxidants in newly diagnosed type 2 diabetes patients with tobacco chewing habit. It is known that hyperglycemia induces oxidative stress and further facilitate the progression of diabetic complications.

Bangladesh Journal of Medical Science Vol.18(1) 2019 p.78-82

Downloads

Download data is not yet available.
Abstract
24
PDF
28

Author Biography

Nirjala Laxmi Madhikarmi, Associate Professor, Department of Biochemistry, Kantipur Dental College Teaching hospital & Research center, Kathmandu

Department of Biochemistry

Downloads

Published

2018-12-30

How to Cite

Nagamma, T., Madhikarmi, N. L., & PP, S. (2018). Assessment of oxidative damage and lipid profile levels in tobacco chewers with Type 2 diabetes mellitus. Bangladesh Journal of Medical Science, 18(1), 78–82. https://doi.org/10.3329/bjms.v18i1.39554

Issue

Vol. 18 No. 1 (2019)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.