Relatıonshıp between C-erb-B2 expressıon and other prognostıc factors in gastrıc cancer

Authors

  • Havva Tugba Kiper Yılmaz Erzurum Region Training and Research Hospital, Internal Medicine Clinic, Erzurum
  • Selçuk Ergen Erzurum Region Training and Research Hospital, Medical Oncology Clinic, Erzurum
  • İdris Baydar Erzurum Region Training and Research Hospital, Internal Medicine Clinic, Erzurum
  • Ayşe Çarlıoğlu Erzurum Region Training and Research Hospital, Endocrine and Metabolic Diseases Clinic, Erzurum
  • Ali Kurt Erzurum Region Training and Research Hospital, Pathology Department, Erzurum

DOI:

https://doi.org/10.3329/bjms.v18i1.39562

Keywords:

c-erbB2; Gastric cancer

Abstract

Background: Gastric cancer-related deaths are among the leading causes of cancer-related deaths. Clinical trials with targeted agents continue in the treatment of stomach cancer, with randomized trials of chemotherapy to prolong survival in the treatment of metastatic gastric cancer. Metastatic stomach cancer treatment is also becoming increasingly personalized to the characteristics of the patient and tumor as it is in breast cancer.

Result: Trastuzumab has shown randomized trial (TOGA study) in c-erbB2 positive metastatic stomach and gastroesophageal junction adenocancer patients to prolong median survival.Immunohistochemically, the presence of cerbB2 positivity and scoring at the time of diagnosis or in the resection material suggests that patients, especially in the metastatic stage, is necessary. The grade (score) of Cebb2 positivity was more pronounced in adenocarcinomas especially located anatomically close to the gastroesophageal junction.

Conclusion: In our study, it was aimed to reveal the relationship between the demographic characteristics of patients who are candidates for treatment and the level of cerbB2 positivity and anatomic localization, especially in the metastatic stage if stomach and thyroid cancer are considered to be a common condition in our region.

Bangladesh Journal of Medical Science Vol.18(1) 2019 p.124-129

Downloads

Download data is not yet available.
Abstract
23
PDF
20

Downloads

Published

2018-12-30

How to Cite

Yılmaz, H. T. K., Ergen, S., Baydar, İdris, Çarlıoğlu, A., & Kurt, A. (2018). Relatıonshıp between C-erb-B2 expressıon and other prognostıc factors in gastrıc cancer. Bangladesh Journal of Medical Science, 18(1), 124–129. https://doi.org/10.3329/bjms.v18i1.39562

Issue

Vol. 18 No. 1 (2019)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.