The Effects Comparisons of Sauropus androgynous, Moringa oleiefera alone and in combination on iron deficiency in anemia rats

Authors

  • Ulfah Dian Indrayani Department of Histology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia
  • Hadi Sarosa Department of Physiology Faculty of Medicine Sultan Agung Islamic University, Semarang, Indonesia
  • Atina Hussaana Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia
  • Bagas Widiyanto Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia

DOI:

https://doi.org/10.3329/bjms.v18i1.39564

Keywords:

Sauropus androgynous extract; Moringaoleiefera extract; Combination extract; antianemia

Abstract

Background: Leaves extract of Sauropus androgynous (Sa) or Moringaoleiefera(Mo) alone has been shown to increase hemoglobin level in iron deficiency anemia. The combination of the two extracts have been known to potentially have a synergistic effect on anemia. The objective of this study is to compare the anti-anemic effect of Sa, Mo alone and their combination on iron deficiency anemia in rats.

Methods: Thirty female wistarstrain rats were randomly divided into 5 groups: normal, iron deficiency anemia, Sa, Mo and the combination of Sa and Mo. Beside the normal group, rats were fed Fe-deficient diet to induce iron-deficiency anemia. Level of hemoglobin, ferritin and plasma MDA were measured on day 8 (after induction of anemia) and day 29. Data were analyzed using One Way ANOVA followed by LSD post hoc test.

Result: The rats fed with Fe-deficient diet for 7 days shown significantly had a lower plasma Hb and ferritin levels and higher plasma MDA levels compared to the normal group (p <0.05) After the treatment, the rats given the extracts significantly had a higher mean of Hb and Ferritin and a lower mean of MDA level compared to anemic control. The mean Hb, ferritin and MDA level of the combination group were close to normal group.

Conclusion: The combination of the leaves extract of Sauropus androgynous or Moringaoleiefera is more effective against iron deficiency anemia compared to extract alone in rats.

Bangladesh Journal of Medical Science Vol.18(1) 2019 p.136-140

Downloads

Download data is not yet available.
Abstract
27
PDF
34

Author Biographies

Ulfah Dian Indrayani, Department of Histology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia

Faculty of Medicine

Atina Hussaana, Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia

Faculty of Medicine

Bagas Widiyanto, Department of Pharmacology, Faculty of Medicine, Sultan Agung Islamic University, Semarang, Indonesia

Faculty of Medicine

Downloads

Published

2018-12-30

How to Cite

Indrayani, U. D., Sarosa, H., Hussaana, A., & Widiyanto, B. (2018). The Effects Comparisons of Sauropus androgynous, Moringa oleiefera alone and in combination on iron deficiency in anemia rats. Bangladesh Journal of Medical Science, 18(1), 136–140. https://doi.org/10.3329/bjms.v18i1.39564

Issue

Vol. 18 No. 1 (2019)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.