Antioxidant activities of dithiol alpha-lipoic acid

Authors

  • Mohammad Toowhidul Islam Associate Professor, Department of Pharmacology & Therapeutics, Kumudini Women?s Medical College & Hospital, Tangail, Bangladesh

DOI:

https://doi.org/10.3329/bjms.v8i3.3982

Keywords:

Antioxidant, free radical, alpha-lipoic acid

Abstract

Alpha-lipoic acid, a dithiol compound derived from octanoic acid, which acts as a coenzyme for several redox reactions in almost all the tissue of the body. It retains its protective functions in both oxidized and reduced forms. Alpha-lipoic acid reduces oxidative stress by redox generation of other antioxidants such as vitamin C, E and increasing the intracellular glutathione. Exogenous alpha-lipoic acid has been shown to increase ATP production due to its role in the oxidation of pyruvate and alpha-ketoglutarate in the mitochondria. Alpha-lipoic acid administration has been shown to be effective in preventing pathology in various experimental models in which reactive oxygen species have been implicated.

Key words: Antioxidant, free radical, alpha-lipoic acid  

DOI: 10.3329/bjms.v8i3.3982

Bangladesh Journal of Medical Sciences Vol.8(3) 2009 p46-51

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How to Cite

Islam, M. T. (2009). Antioxidant activities of dithiol alpha-lipoic acid. Bangladesh Journal of Medical Science, 8(3), 46–51. https://doi.org/10.3329/bjms.v8i3.3982

Issue

Vol. 8 No. 3 (2009)

Section

Review Article

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