Role of serum cardiac Troponin-I for risk stratification in first attack in acute myocardial infarction

Authors

  • Md Sahabuddin Joarder Associate Professor, Department of Biochemistry, Z. H. Sikder Women?s Medical College
  • Md Jafarullah Professor (C.C.), Department of Biochemistry, Medical College for Women & Hospital, Uttara, Dhaka-1230
  • Ahmed Moinuddin Assistant Professor, Medical College for Women & Hospital, Uttara, Dhaka-1230

DOI:

https://doi.org/10.3329/bjms.v8i3.3984

Keywords:

Cardiac Troponin-I, acute myocardial infarction, risk stratification

Abstract

Introduction: Cardiac troponin-I (cTnI) is known to have the highest specificity and analytic sensitivity for detection of myocardial injury; it is used both as diagnostic and prognostic marker. This study was aimed to confirm this idea.

Subjects & methods: This prospective observational study included 60 patients of 40 to 65 years age range diagnosed as acute myocardial infarction. The mean ages were 50±8 years and 53±8 years in Q -wave AMI and non Q-wave AMI respectively. Male and female patients included were 86.7% and 13.3%; BMI was 25.3±1.5.

Results: Study showed troponin-I 7.53±0.086 ng/ml in Q wave and in non Q-wave AMI was 6.38±0.64 ng/ml after 24 hours of attack of AMI without any significant difference between two groups (P>0.05). The mean troponin-I within 9 hours of attack, were 1.60±0.80 ng/ml and 2.7±1.4 ng/ml in stable and unstable group respectively and the difference found statistically significant (P<0.05). The mean troponin-I between 9-24 hours of attack were 2.90±1.20 ng/ml and 4.90±3.20 ng/ml in stable and unstable group respectively and the difference found statistically significant (P<0.01). The mean troponin-I in unstable group after 24 hours was 9.20±4.30 ng/ml which was more than between 9-24 hours and the difference was significant (P>0.001). In clinicopathological outcome evaluation 37 patients had troponin-I level >1.5 ng/ml in which 29 patients developed unstability and 8 patients were stable.

Conclusion: Serum cTnI is better and more characteristic biomarker for risk prediction and prognosis evaluation in AMI patients.

Key words: Cardiac Troponin-I, acute myocardial infarction, risk stratification.  

DOI: 10.3329/bjms.v8i3.3984

Bangladesh Journal of Medical Sciences Vol.8(3) 2009 p57-63

Downloads

Download data is not yet available.
Abstract
63
PDF
86

Downloads

How to Cite

Joarder, M. S., Jafarullah, M., & Moinuddin, A. (2009). Role of serum cardiac Troponin-I for risk stratification in first attack in acute myocardial infarction. Bangladesh Journal of Medical Science, 8(3), 57–63. https://doi.org/10.3329/bjms.v8i3.3984

Issue

Vol. 8 No. 3 (2009)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.