Role of serum cardiac Troponin-I for risk stratification in first attack in acute myocardial infarction

Authors

  • Md Sahabuddin Joarder Associate Professor, Department of Biochemistry, Z. H. Sikder Women?s Medical College
  • Md Jafarullah Professor (C.C.), Department of Biochemistry, Medical College for Women & Hospital, Uttara, Dhaka-1230
  • Ahmed Moinuddin Assistant Professor, Medical College for Women & Hospital, Uttara, Dhaka-1230

DOI:

https://doi.org/10.3329/bjms.v8i3.3984

Keywords:

Cardiac Troponin-I, acute myocardial infarction, risk stratification

Abstract

Introduction: Cardiac troponin-I (cTnI) is known to have the highest specificity and analytic sensitivity for detection of myocardial injury; it is used both as diagnostic and prognostic marker. This study was aimed to confirm this idea.

Subjects & methods: This prospective observational study included 60 patients of 40 to 65 years age range diagnosed as acute myocardial infarction. The mean ages were 50±8 years and 53±8 years in Q -wave AMI and non Q-wave AMI respectively. Male and female patients included were 86.7% and 13.3%; BMI was 25.3±1.5.

Results: Study showed troponin-I 7.53±0.086 ng/ml in Q wave and in non Q-wave AMI was 6.38±0.64 ng/ml after 24 hours of attack of AMI without any significant difference between two groups (P>0.05). The mean troponin-I within 9 hours of attack, were 1.60±0.80 ng/ml and 2.7±1.4 ng/ml in stable and unstable group respectively and the difference found statistically significant (P<0.05). The mean troponin-I between 9-24 hours of attack were 2.90±1.20 ng/ml and 4.90±3.20 ng/ml in stable and unstable group respectively and the difference found statistically significant (P<0.01). The mean troponin-I in unstable group after 24 hours was 9.20±4.30 ng/ml which was more than between 9-24 hours and the difference was significant (P>0.001). In clinicopathological outcome evaluation 37 patients had troponin-I level >1.5 ng/ml in which 29 patients developed unstability and 8 patients were stable.

Conclusion: Serum cTnI is better and more characteristic biomarker for risk prediction and prognosis evaluation in AMI patients.

Key words: Cardiac Troponin-I, acute myocardial infarction, risk stratification.  

DOI: 10.3329/bjms.v8i3.3984

Bangladesh Journal of Medical Sciences Vol.8(3) 2009 p57-63

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How to Cite

Joarder, M. S., Jafarullah, M., & Moinuddin, A. (2009). Role of serum cardiac Troponin-I for risk stratification in first attack in acute myocardial infarction. Bangladesh Journal of Medical Science, 8(3), 57–63. https://doi.org/10.3329/bjms.v8i3.3984

Issue

Vol. 8 No. 3 (2009)

Section

Original Articles

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