Correlation between Digit Ratio and Incidence of Meningioma and its Clinical Profiles

Authors

  • Surya Pratama Brilliantika Student of Faculty of Medicine Diponegoro University, Semarang Indonesia
  • Muhammad Thohar Arifin Anatomy Department Faculty of Medicine, Diponegoro University, Semarang Indonesia
  • Hermawan Istiadi Pathology Anatomy Department Faculty of Medicine, Diponegoro University, Semarang Indonesia
  • Tri Indah Winarni Anatomy Department Faculty of Medicine, Diponegoro University, Semarang Indonesia
  • Hexanto Muhartomo Neurology Department Faculty of Medicine, Diponegoro University, Semarang Indonesia

DOI:

https://doi.org/10.3329/bjms.v18i2.40707

Keywords:

Meningioma; Digit Ratio

Abstract

Background: Proliferation and progression of meningioma were influenced by the balance of estrogen and testosterone. Digit Ratio (DR) was a sign of prenatal exposure to estrogen and testosterone. This study intends to find the relationship between Digit Ratio and meningioma.

Aim: To determine the relationship between DR and incidence of Meningioma and its Clinical Profiles (age at the onset, sex, Body Mass Indec (BMI) and histopathology grading)

Methods: Analytical observational study was used with case-control design. Case group consisted of patients clinically and histopathologically diagnosed with meningioma (n=25). Patients who were not diagnosed with primary intracranial tumors were included in the control group (n=25). Matched group were conducted. Subjects of this study were patients of RSUP dr Kariadi in the period of January 2016-August 2017. This study was conducted by collecting data consisted of DR, age, sex, BMI, and grading histopathology. Tests used in this study are Chi-Square Test, Mann-Whitney Test and Fishers exact Test.

Results: Digit Ratio Mean for right, left and right-left difference were 1.0041; 1.0104 and 0.0357 while for the right and left DR cutoff value 0.993; 0.989. There is a relationship between right and left Digit Ratio and incidence of meningioma (p = 0,000) with OR (Odds Ratio) Right DR = 11.17(CI95% 2,864 – 43,464) and OR left DR = 16,00 (CI95% 4,002 – 63,975). There is a relationship between Right Digit Ratio andBMI case group (p = 0,022). There is no relationship of Digit Ratio and age at onset, gender and histopathology grading (p <0.05).

Conclusion: DR is risk factor of Meningioma

Bangladesh Journal of Medical Science Vol.18(2) 2019 p.347-352

Downloads

Download data is not yet available.
Abstract
937
PDF
589

Downloads

Published

2019-03-25

How to Cite

Brilliantika, S. P., Arifin, M. T., Istiadi, H., Winarni, T. I., & Muhartomo, H. (2019). Correlation between Digit Ratio and Incidence of Meningioma and its Clinical Profiles. Bangladesh Journal of Medical Science, 18(2), 347–352. https://doi.org/10.3329/bjms.v18i2.40707

Issue

Vol. 18 No. 2 (2019)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.