Effects on thrombocytic hemostasis of a new derivate indolinone

Authors

  • VV Bykov Siberian State Medical University (SSMU) of Russian Ministry of Health, Tomsk, Russia
  • V Yu Serebrov Siberian State Medical University (SSMU) of Russian Ministry of Health, Tomsk, Russia
  • VV Udut Tomsk National Research Medical Center of the Russian Academy of Sciences, Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, and National Research Tomsk State University, Tomsk, Russia
  • EV Udut Siberian State Medical University (SSMU) of Russian Ministry of Health, Tomsk, Russia
  • VP Fisenko First Moscow State Medical University of the Ministry of Health, Moscow, Russia

DOI:

https://doi.org/10.3329/bjms.v18i3.41628

Keywords:

antiplatelet, indolinone derivative, acetylsalicylic acid, dipyridamole, platelet aggregation

Abstract

Objective. Specific activity of an antiplatelet drug of indolinone series (codenamed DI) was studied in vitro in a model of ADP-induced platelet aggregation in vitro and in vivo in a model of streptozotocininduced diabetes mellitus in rats.

Material and Methods. Acetylsalicylic acid and dipyridamole were used as reference drugs. In vitro tests have demonstrated that DI exhibits antiplatelet activity in a wide range of concentrations (0,75×10-6 – 1.5×10-5 М, р<0,05), being comparable to acetylsalicylic acid and dipyridamole. In vivo tests have demonstrated dose-dependent antiplatelet activity of DI in doses of 2,5 – 20 mg/kg (21-14 %).

Results and Discussion.Increasing the dose of DI above 10 mg/kg doesn’t increase its antiplatelet activity. After multiple oral administration to rats with streptozotocin-induced diabetes mellitus in 10 mg/kg dose, DI has exhibited antiplatelet activity, reducing the platelet aggregation rate to that of the control group (р<0,05).

Conclusion. Thus, DI isapromisingcompound for furtherdevelopmentof an antiplatelet drug with new mechanism of action

Bangladesh Journal of Medical Science Vol.18(3) 2019 p.574-576

Downloads

Download data is not yet available.
Abstract
526
PDF
491

Downloads

Published

2019-05-30

How to Cite

Bykov, V., Serebrov, V. Y., Udut, V., Udut, E., & Fisenko, V. (2019). Effects on thrombocytic hemostasis of a new derivate indolinone. Bangladesh Journal of Medical Science, 18(3), 574–576. https://doi.org/10.3329/bjms.v18i3.41628

Issue

Vol. 18 No. 3 (2019)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.